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6VBA

Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA)

Summary for 6VBA
Entry DOI10.2210/pdb6vba/pdb
Related1AKZ
DescriptorUracil-DNA glycosylase, 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid) (3 entities in total)
Functional Keywordsglycosylase, dna repair, uracil removal from dna, alpha/ beta protein, glycosidase, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight25966.48
Authors
Moiani, D.,Arvai, A.S.,Tainer, J.A. (deposition date: 2019-12-18, release date: 2021-03-03, Last modification date: 2023-10-11)
Primary citationNguyen, M.T.,Moiani, D.,Ahmed, Z.,Arvai, A.S.,Namjoshi, S.,Shin, D.S.,Fedorov, Y.,Selvik, E.J.,Jones, D.E.,Pink, J.,Yan, Y.,Laverty, D.J.,Nagel, Z.D.,Tainer, J.A.,Gerson, S.L.
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Prog.Biophys.Mol.Biol., 163:143-159, 2021
Cited by
PubMed: 33675849
DOI: 10.1016/j.pbiomolbio.2021.02.004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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