8C8J
 
 | | Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP | | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, ... | | 著者 | Nichols, C.E, Walpole, T.B, Baldwin, E. | | 登録日 | 2023-01-20 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024
|
|
4BSQ
 | | MOUSE CATHEPSIN S WITH COVALENT LIGAND | | 分子名称: | (1R,2R,4R)-N-(2-azanylideneethyl)-2-morpholin-4-ylcarbonyl-4-(phenylsulfonyl)cyclopentane-1-carboxamide, CATHEPSIN S, SULFATE ION | | 著者 | Banner, D.W, Benz, J, Gsell, B, Stihle, M, Ruf, A, Hilpert, H. | | 登録日 | 2013-06-11 | | 公開日 | 2013-11-27 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Identification of Potent and Selective Cathepsin S (Cats) Inhibitors Containing Different Central Cyclic Scaffolds.
J.Med.Chem., 56, 2013
|
|
4BS5
 | | MOUSE CATHEPSIN S WITH COVALENT LIGAND | | 分子名称: | (2S,4R)-N-[1-(iminomethyl)cyclopropyl]-4-[2-(trifluoromethyl)phenyl]sulfonyl-pyrrolidine-2-carboxamide, CATHEPSIN S | | 著者 | Banner, D.W, Benz, J, Gsell, B, Stihle, M, Ruf, A, Haap, W. | | 登録日 | 2013-06-07 | | 公開日 | 2013-11-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Identification of Potent and Selective Cathepsin S (Cats) Inhibitors Containing Different Central Cyclic Scaffolds.
J.Med.Chem., 56, 2013
|
|
1JSP
 | | NMR Structure of CBP Bromodomain in complex with p53 peptide | | 分子名称: | CREB-BINDING PROTEIN, tumor protein p53 | | 著者 | He, Y, Mujtaba, S, Zeng, L, Yan, S, Zhou, M.-M. | | 登録日 | 2001-08-17 | | 公開日 | 2002-08-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
|
|
8SXU
 | |
1QFD
 | | NMR SOLUTION STRUCTURE OF ALPHA-AMYLASE INHIBITOR (AAI) | | 分子名称: | PROTEIN (ALPHA-AMYLASE INHIBITOR) | | 著者 | Lu, S, Deng, P, Liu, X, Luo, J, Han, R, Gu, X, Liang, S, Wang, X, Feng, L, Lozanov, V, Patthy, A, Pongor, S. | | 登録日 | 1999-04-08 | | 公開日 | 1999-07-16 | | 最終更新日 | 2024-10-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the major alpha-amylase inhibitor of the crop plant amaranth.
J.Biol.Chem., 274, 1999
|
|
8SXT
 | | Structure of LINE-1 ORF2p with template:primer hybrid | | 分子名称: | DNA primer, LINE-1 retrotransposable element ORF2 protein, MAGNESIUM ION, ... | | 著者 | van Eeuwen, T, Taylor, M.S, Rout, M.P. | | 登録日 | 2023-05-24 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024
|
|
8E8V
 | |
8E8U
 | | Structure of the LOR domain of human AASS | | 分子名称: | Alpha-aminoadipic semialdehyde synthase, mitochondrial, MAGNESIUM ION | | 著者 | Khamrui, S, Lazarus, M.B. | | 登録日 | 2022-08-25 | | 公開日 | 2022-10-05 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.
Open Biology, 12, 2022
|
|
8E8T
 | | Structure of the short LOR domain of human AASS | | 分子名称: | Alpha-aminoadipic semialdehyde synthase, mitochondrial | | 著者 | Khamrui, S, Lazarus, M.B. | | 登録日 | 2022-08-25 | | 公開日 | 2022-10-05 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.
Open Biology, 12, 2022
|
|
3TAM
 | |
6U3J
 | |
6UWY
 | | DYRK1A bound to a harmine derivative | | 分子名称: | 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, TETRAETHYLENE GLYCOL | | 著者 | Khamrui, S, Lazarus, M.B. | | 登録日 | 2019-11-05 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human beta-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.
J.Med.Chem., 63, 2020
|
|
3T1A
 | |
3T19
 | |
7B04
 | | Structure of Nitrite oxidoreductase (Nxr) from the anammox bacterium Kuenenia stuttgartiensis. | | 分子名称: | CALCIUM ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ... | | 著者 | Moreno-Chicano, T, Dietl, A, Akram, M, Barends, T.R.M. | | 登録日 | 2020-11-18 | | 公開日 | 2021-07-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex
Nat Microbiol, 2021
|
|
7R62
 | | Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative | | 分子名称: | 11-[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]-N-methyl-N-propylundecanamide, Estrogen receptor | | 著者 | Diennet, M, El Ezzy, M, Thiombane, K, Cotnoir-White, D, Poupart, J, Gao, Z, Mendoza Sanchez, R, Marinier, A, Gleason, J, Greene, G.L, Mader, S.C, Fanning, S.W. | | 登録日 | 2021-06-22 | | 公開日 | 2022-07-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative
To Be Published
|
|
