3TAM
Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06
Summary for 3TAM
Entry DOI | 10.2210/pdb3tam/pdb |
Related | 3T19 3T1A |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 3-chloro-5-{[4-methyl-2-oxo-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile, ... (4 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltranferase, k103n, hiv-1, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | HIV-1 M:B_HXB2R (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116988.39 |
Authors | |
Primary citation | Gomez, R.,Jolly, S.,Williams, T.,Tucker, T.,Tynebor, R.,Vacca, J.,McGaughey, G.,Lai, M.T.,Felock, P.,Munshi, V.,DeStefano, D.,Touch, S.,Miller, M.,Yan, Y.,Sanchez, R.,Liang, Y.,Paton, B.,Wan, B.L.,Anthony, N. Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase. Bioorg.Med.Chem.Lett., 21:7344-7350, 2011 Cited by PubMed: 22071300DOI: 10.1016/j.bmcl.2011.10.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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