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3T19

Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05

Summary for 3T19
Entry DOI10.2210/pdb3t19/pdb
Related3T1A 3TAM
DescriptorReverse Transcriptase, 1-(2,5-dichloro-3-{[5-chloro-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-benzotriazol-4-yl]oxy}phenyl)methanamine (3 entities in total)
Functional Keywordshiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, hiv-1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHIV-1 M:B_HXB2R (HIV-1)
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
Total number of polymer chains2
Total formula weight130265.36
Authors
Yan, Y.,Reid, J. (deposition date: 2011-07-21, release date: 2011-10-26, Last modification date: 2023-09-13)
Primary citationGomez, R.,Jolly, S.J.,Williams, T.,Vacca, J.P.,Torrent, M.,McGaughey, G.,Lai, M.T.,Felock, P.,Munshi, V.,Distefano, D.,Flynn, J.,Miller, M.,Yan, Y.,Reid, J.,Sanchez, R.,Liang, Y.,Paton, B.,Wan, B.L.,Anthony, N.
Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.
J.Med.Chem., 54:7920-7933, 2011
Cited by
PubMed: 21985673
DOI: 10.1021/jm2010173
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

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