6UWY

DYRK1A bound to a harmine derivative

Summary for 6UWY

Entry DOI	10.2210/pdb6uwy/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide, TETRAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	171652.03
Authors	Khamrui, S.,Lazarus, M.B. (deposition date: 2019-11-05, release date: 2020-02-12, Last modification date: 2023-11-15)
Primary citation	Kumar, K.,Wang, P.,Wilson, J.,Zlatanic, V.,Berrouet, C.,Khamrui, S.,Secor, C.,Swartz, E.A.,Lazarus, M.,Sanchez, R.,Stewart, A.F.,Garcia-Ocana, A.,DeVita, R.J. Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human beta-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor. J.Med.Chem., 63:2986-3003, 2020 Cited by PubMed: 32003560 DOI: 10.1021/acs.jmedchem.9b01379 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation