4BS5

MOUSE CATHEPSIN S WITH COVALENT LIGAND

Summary for 4BS5

Entry DOI	10.2210/pdb4bs5/pdb
Related	4BQV 4BS6 4BSQ
Descriptor	CATHEPSIN S, (2S,4R)-N-[1-(iminomethyl)cyclopropyl]-4-[2-(trifluoromethyl)phenyl]sulfonyl-pyrrolidine-2-carboxamide (3 entities in total)
Functional Keywords	hydrolase, cysteine protease, covalent ligand
Biological source	MUS MUSCULUS (HOUSE MOUSE)
Cellular location	Lysosome: O70370
Total number of polymer chains	1
Total formula weight	25051.87
Authors	Banner, D.W.,Benz, J.,Gsell, B.,Stihle, M.,Ruf, A.,Haap, W. (deposition date: 2013-06-07, release date: 2013-11-27, Last modification date: 2014-01-15)
Primary citation	Hilpert, H.,Mauser, H.,Humm, R.,Anselm, L.,Kuehne, H.,Hartmann, G.,Gruener, S.,Banner, D.W.,Benz, J.,Gsell, B.,Kuglstatter, A.,Stihle, M.,Thoma, R.,Alvarez-Sanchez, R.,Iding, H.,Wirz, B.,Haap, W. Identification of Potent and Selective Cathepsin S (Cats) Inhibitors Containing Different Central Cyclic Scaffolds. J.Med.Chem., 56:9789-, 2013 Cited by PubMed: 24224654 DOI: 10.1021/JM401528K PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation