8C8J
Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP
Summary for 8C8J
Entry DOI | 10.2210/pdb8c8j/pdb |
Descriptor | RNA-directed DNA polymerase, CHLORIDE ION, DNA (5'-D(P*GP*CP*GP*CP*TP*TP*TP*CP*C)-3'), ... (11 entities in total) |
Functional Keywords | reverse transcriptase, rt, dttp, hyrbid duplex, template primer, replication |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 106642.63 |
Authors | Nichols, C.E.,Walpole, T.B.,Baldwin, E. (deposition date: 2023-01-20, release date: 2023-12-20, Last modification date: 2024-02-14) |
Primary citation | Baldwin, E.T.,van Eeuwen, T.,Hoyos, D.,Zalevsky, A.,Tchesnokov, E.P.,Sanchez, R.,Miller, B.D.,Di Stefano, L.H.,Ruiz, F.X.,Hancock, M.,Isik, E.,Mendez-Dorantes, C.,Walpole, T.,Nichols, C.,Wan, P.,Riento, K.,Halls-Kass, R.,Augustin, M.,Lammens, A.,Jestel, A.,Upla, P.,Xibinaku, K.,Congreve, S.,Hennink, M.,Rogala, K.B.,Schneider, A.M.,Fairman, J.E.,Christensen, S.M.,Desrosiers, B.,Bisacchi, G.S.,Saunders, O.L.,Hafeez, N.,Miao, W.,Kapeller, R.,Zaller, D.M.,Sali, A.,Weichenrieder, O.,Burns, K.H.,Gotte, M.,Rout, M.P.,Arnold, E.,Greenbaum, B.D.,Romero, D.L.,LaCava, J.,Taylor, M.S. Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature, 626:194-206, 2024 Cited by PubMed: 38096902DOI: 10.1038/s41586-023-06947-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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