8C8J
Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-directed DNA polymerase | polymer | 832 | 98020.7 | 1 | UniProt (G8I2S9) Pfam (PF00078) UniProt (by SIFTS) (O00370) | Homo sapiens (human) | |
| 2 | B (B) | DNA (5'-D(P*GP*CP*GP*CP*TP*TP*TP*CP*C)-3') | polymer | 9 | 2682.8 | 1 | synthetic construct | ||
| 3 | C (C) | RNA (5'-R(P*UP*UP*AP*GP*GP*AP*AP*AP*GP*CP*GP*C)-3') | polymer | 12 | 3875.4 | 1 | synthetic construct | ||
| 4 | D, P (A) | CITRIC ACID | non-polymer | 192.1 | 2 | Chemie (CIT) | |||
| 5 | E (A) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 1 | Chemie (TTP) | |||
| 6 | F, H, I, J, K... (A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 7 | G, M (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 8 | R (A) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 1 | Chemie (DIO) | |||
| 9 | W, X (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 10 | Y (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 11 | AA, BA, CA (A, B, C) | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A: 238 - 1061 (UniProt: G8I2S9)
| PDB | External Database | Details |
|---|---|---|
| Asp 434 | Asn 434 | conflict |
| His 910 | Leu 910 | conflict |
| His 1062 | - | expression tag |
| His 1063 | - | expression tag |
| His 1064 | - | expression tag |
| His 1065 | - | expression tag |
| His 1066 | - | expression tag |
| His 1067 | - | expression tag |
| His 1068 | - | expression tag |
| His 1069 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 104578.8 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2063.8 | |
| All* | Total formula weight | 106642.6 |
