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3WPG
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BU of 3wpg by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.246 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPI
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BU of 3wpi by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA_super
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*CP*AP*AP*TP*AP*GP*GP*GP*TP*GP*AP*GP*GP*GP*G)-3'), Toll-like receptor 9
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.246 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPE
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BU of 3wpe by Molmil
Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer
分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3'), Toll-like receptor 9
著者Ohto, U, Tanji, H, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPH
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BU of 3wph by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.327 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPC
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BU of 3wpc by Molmil
Crystal structure of horse TLR9 in complex with agonistic DNA1668_12mer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3'), ...
著者Ohto, U, Tanji, H, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
8WX5
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BU of 8wx5 by Molmil
Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
分子名称: Solute carrier family 15 member 4, TASL (TASL-SLC15A4 fusion protein)
著者Ohto, U, Zhang, Z, Fujimura, A, Shimizu, T.
登録日2023-10-27
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
To Be Published
7C77
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BU of 7c77 by Molmil
Cryo-EM structure of mouse TLR3 in complex with UNC93B1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2020-05-23
公開日2021-01-06
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
7C76
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BU of 7c76 by Molmil
Cryo-EM structure of human TLR3 in complex with UNC93B1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2020-05-23
公開日2021-01-06
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
7CYN
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BU of 7cyn by Molmil
Cryo-EM structure of human TLR7 in complex with UNC93B1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2020-09-03
公開日2021-01-06
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
3W67
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BU of 3w67 by Molmil
Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(3,4)-bisphosphate
分子名称: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, Alpha-tocopherol transfer protein
著者Ohto, U, Satow, Y.
登録日2013-02-11
公開日2013-05-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340, 2013
3W68
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BU of 3w68 by Molmil
Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(4,5)-bisphosphate
分子名称: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, ...
著者Ohto, U, Satow, Y.
登録日2013-02-11
公開日2013-05-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340, 2013
5IRN
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BU of 5irn by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form1)
分子名称: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
著者Maekawa, S, Ohto, U, Shimizu, T.
登録日2016-03-14
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
6LVY
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BU of 6lvy by Molmil
Crystal structure of TLR7/Cpd-2 (SM-360320) complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2020-02-06
公開日2020-11-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LW0
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BU of 6lw0 by Molmil
Crystal structure of TLR7/Cpd-6 (DSR-139293) complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2020-02-06
公開日2020-11-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
8HRX
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BU of 8hrx by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex
分子名称: Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2022-12-16
公開日2024-01-17
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
8HRY
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BU of 8hry by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex
分子名称: Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2022-12-16
公開日2024-01-17
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
3M7O
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BU of 3m7o by Molmil
Crystal structure of mouse MD-1 in complex with phosphatidylcholine
分子名称: (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ...
著者Harada, H, Ohto, U, Satow, Y.
登録日2010-03-17
公開日2010-06-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity
J.Mol.Biol., 400, 2010
8WX3
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BU of 8wx3 by Molmil
Cryo-EM structure of human SLC15A4 (outward-facing open)
分子名称: Solute carrier family 15 member 4
著者Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-06
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Cryo-EM structure of human SLC15A4 (outward-facing open)
To Be Published
8WX2
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BU of 8wx2 by Molmil
Cryo-EM structure of human SLC15A3 (dimer)
分子名称: Solute carrier family 15 member 3
著者Kasai, S, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-06
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)
To Be Published
8WX4
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BU of 8wx4 by Molmil
Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
分子名称: LEUCINE, LYSINE, Solute carrier family 15 member 4
著者Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
To Be Published
8KCW
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BU of 8kcw by Molmil
Cryo-EM structure of human SIDT1 bound to cholesterol
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SID1 transmembrane family member 1, ...
著者Hirano, Y, Ohto, U, Shimizu, T.
登録日2023-08-08
公開日2024-06-12
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity.
Commun Biol, 7, 2024
8KCX
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BU of 8kcx by Molmil
Cryo-EM structure of human SIDT1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SID1 transmembrane family member 1, ZINC ION, ...
著者Hirano, Y, Ohto, U, Shimizu, T.
登録日2023-08-08
公開日2024-06-12
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity.
Commun Biol, 7, 2024
6LW1
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BU of 6lw1 by Molmil
Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form
分子名称: 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2020-02-06
公開日2020-11-11
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LVZ
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BU of 6lvz by Molmil
Crystal structure of TLR7/Cpd-3 (SM-394830) complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2020-02-06
公開日2020-11-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LVX
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BU of 6lvx by Molmil
Crystal structure of TLR7/Cpd-1 (SM-374527) complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2020-02-06
公開日2020-11-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020

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