3NG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ng5 by Molmil](/molmil-images/mine/3ng5) | Crystal Structure of V30M transthyretin complexed with (-)-epigallocatechin gallate (EGCG) | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, GLYCEROL, Transthyretin | 著者 | Miyata, M, Nakamura, T, Ikemizu, S, Chirifu, M, Yamagata, Y, Kai, H. | 登録日 | 2010-06-11 | 公開日 | 2010-07-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of green tea polyphenol(-)-epigallocatechin gallate (EGCG)-transthyretin complex reveals novel binding site distinct from thyroxine binding site Biochemistry, 2010
|
|
8II1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ii1 by Molmil](/molmil-images/mine/8ii1) | Crystal structure of V30M-TTR in complex with BID | 分子名称: | Benziodarone, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.907 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
|
|
8II3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ii3 by Molmil](/molmil-images/mine/8ii3) | Crystal structure of V30M-TTR in complex with 6-hydroxy BID | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
|
|
8II4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ii4 by Molmil](/molmil-images/mine/8ii4) | Crystal structure of V30M-TTR in complex with 6-hydroxy BBM | 分子名称: | Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
|
|
8II2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ii2 by Molmil](/molmil-images/mine/8ii2) | Crystal structure of V30M-TTR in complex with BBM | 分子名称: | CALCIUM ION, Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-02-24 | 公開日 | 2023-06-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90, 2023
|
|
3A4D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3a4d by Molmil](/molmil-images/mine/3a4d) | |
3A4F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3a4f by Molmil](/molmil-images/mine/3a4f) | Crystal Structure of Human Transthyretin (E54K) | 分子名称: | GLYCEROL, SULFATE ION, Transthyretin | 著者 | Miyata, M, Sato, T, Nakamura, T, Ikemizu, S, Yamagata, Y, Kai, H. | 登録日 | 2009-07-06 | 公開日 | 2009-12-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding Biochemistry, 49, 2010
|
|
3A4E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3a4e by Molmil](/molmil-images/mine/3a4e) | Crystal structure of Human Transthyretin (E54G) | 分子名称: | GLYCEROL, SULFATE ION, Transthyretin | 著者 | Miyata, M, Sato, T, Nakamura, T, Ikemizu, S, Yamagata, Y, Kai, H. | 登録日 | 2009-07-06 | 公開日 | 2009-12-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding Biochemistry, 49, 2010
|
|
7F4X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7f4x by Molmil](/molmil-images/mine/7f4x) | Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... | 著者 | Yokoyama, T, Ostermann, A, Schrader, T.E. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION | 主引用文献 | Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
|
|
8WGT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wgt by Molmil](/molmil-images/mine/8wgt) | Crystal structure of V30M-TTR in complex with compound 7 | 分子名称: | Transthyretin, [4,7-bis(chloranyl)-2-ethyl-1-benzofuran-3-yl]-[3,5-bis(iodanyl)-4-oxidanyl-phenyl]methanone | 著者 | Yokoyama, T. | 登録日 | 2023-09-22 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
|
|
8WGS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wgs by Molmil](/molmil-images/mine/8wgs) | Crystal structure of V30M-TTR in complex with compound 4 | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-4-iodanyl-1-benzofuran-3-yl)methanone | 著者 | Yokoyama, T. | 登録日 | 2023-09-22 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
|
|
8WGU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wgu by Molmil](/molmil-images/mine/8wgu) | Crystal structure of V30M-TTR in complex with compound 20 | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-[2-ethyl-4,7-bis(fluoranyl)-1-benzofuran-3-yl]methanone | 著者 | Yokoyama, T. | 登録日 | 2023-09-22 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.508 Å) | 主引用文献 | Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
|
|
8IG1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ig1 by Molmil](/molmil-images/mine/8ig1) | |
8JOK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jok by Molmil](/molmil-images/mine/8jok) | |
8JNU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jnu by Molmil](/molmil-images/mine/8jnu) | |
8JQW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jqw by Molmil](/molmil-images/mine/8jqw) | |
8W42
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w42 by Molmil](/molmil-images/mine/8w42) | |
8W44
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w44 by Molmil](/molmil-images/mine/8w44) | |
8W46
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w46 by Molmil](/molmil-images/mine/8w46) | |
8W48
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w48 by Molmil](/molmil-images/mine/8w48) | |
8W43
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w43 by Molmil](/molmil-images/mine/8w43) | |
8W45
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w45 by Molmil](/molmil-images/mine/8w45) | X-ray crystal structure of V30M-TTR in complex with pinostilbene | 分子名称: | 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
|
|
8W47
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w47 by Molmil](/molmil-images/mine/8w47) | X-ray crystal structure of V30M-TTR in complex with isorhapontigenin | 分子名称: | 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
|
|
6IMX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6imx by Molmil](/molmil-images/mine/6imx) | Crystal structure of V30M mutated transthyretin in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J. Med. Chem., 62, 2019
|
|
6IMY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6imy by Molmil](/molmil-images/mine/6imy) | Crystal structure of V30M mutated transthyretin in complex with 4'-caroboxybenzo-18-Crown-6 | 分子名称: | 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecine-18-carboxylic acid, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J. Med. Chem., 62, 2019
|
|