3NG5

Crystal Structure of V30M transthyretin complexed with (-)-epigallocatechin gallate (EGCG)

Summary for 3NG5

Entry DOI	10.2210/pdb3ng5/pdb
Descriptor	Transthyretin, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, GLYCEROL, ... (4 entities in total)
Functional Keywords	retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein, thyroxine
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	29086.06
Authors	Miyata, M.,Nakamura, T.,Ikemizu, S.,Chirifu, M.,Yamagata, Y.,Kai, H. (deposition date: 2010-06-11, release date: 2010-07-07, Last modification date: 2023-11-01)
Primary citation	Miyata, M.,Sato, T.,Kugimiya, M.,Sho, M.,Nakamura, T.,Ikemizu, S.,Chirifu, M.,Mizuguchi, M.,Nabeshima, Y.,Suwa, Y.,Morioka, H.,Arimori, T.,Suico, M.A.,Shuto, T.,Sako, Y.,Momohara, M.,Koga, T.,Morino-Koga, S.,Yamagata, Y.,Kai, H. Crystal structure of green tea polyphenol(-)-epigallocatechin gallate (EGCG)-transthyretin complex reveals novel binding site distinct from thyroxine binding site Biochemistry, 2010 Cited by PubMed: 20565072 DOI: 10.1021/bi1004409 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation