Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070324 | molecular_function | thyroid hormone binding |
| B | 0005179 | molecular_function | hormone activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070324 | molecular_function | thyroid hormone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE KDH A 128 |
| Chain | Residue |
| A | ASP18 |
| A | HOH175 |
| A | HOH186 |
| A | HOH192 |
| A | HOH212 |
| A | HOH214 |
| B | VAL20 |
| B | GLY83 |
| B | SER85 |
| B | TYR114 |
| A | VAL20 |
| A | ARG21 |
| A | TYR78 |
| A | TRP79 |
| A | LEU82 |
| A | LEU82 |
| A | ILE84 |
| A | HOH175 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE KDH A 129 |
| Chain | Residue |
| A | HIS31 |
| A | VAL32 |
| A | PHE33 |
| A | TRP41 |
| A | PRO43 |
| A | PHE44 |
| A | ALA45 |
| A | SER46 |
| A | GLU61 |
| A | GLU62 |
| A | GLU72 |
| A | PRO102 |
| A | HOH136 |
| A | HOH153 |
| A | HOH193 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 130 |
| Chain | Residue |
| A | LEU17 |
| A | ALA108 |
| A | LEU110 |
| A | SER117 |
| A | THR119 |
| A | HOH183 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE KDH B 128 |
| Chain | Residue |
| B | HIS31 |
| B | VAL32 |
| B | PHE33 |
| B | TRP41 |
| B | PRO43 |
| B | PHE44 |
| B | ALA45 |
| B | GLU61 |
| B | GLU72 |
| B | GLY101 |
| B | PRO102 |
| B | HOH175 |
| B | HOH177 |
Functional Information from PROSITE/UniProt
| site_id | PS00769 |
| Number of Residues | 13 |
| Details | TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS |
| Chain | Residue | Details |
| A | TYR105-SER117 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | LYS15 | |
| A | GLU54 | |
| A | SER117 | |
| B | LYS15 | |
| B | GLU54 | |
| B | SER117 | |
| Chain | Residue | Details |
| A | CYS10 | |
| B | CYS10 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012 |
| Chain | Residue | Details |
| A | GLU42 | |
| B | GLU42 | |
| Chain | Residue | Details |
| A | SER52 | |
| B | SER52 | |
| Chain | Residue | Details |
| A | ASN98 | |
| B | ASN98 | |
