Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4OCZ
DownloadVisualize
BU of 4ocz by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
分子名称: 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
著者Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morriseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D.
登録日2014-01-09
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
6HGX
DownloadVisualize
BU of 6hgx by Molmil
Soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl)morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea
分子名称: 1-[4-[[(2~{S})-4-~{tert}-butylmorpholin-2-yl]methoxy]phenyl]-3-cyclohexyl-urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION
著者Kramer, J.S, Pogoryelov, D, Hiesinger, K, Proschak, E.
登録日2018-08-23
公開日2019-07-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Computer-Aided Selective Optimization of Side Activities of Talinolol.
Acs Med.Chem.Lett., 10, 2019
6HGV
DownloadVisualize
BU of 6hgv by Molmil
Soluble epoxide hydrolase in complex with talinolol
分子名称: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, R-Talinolol
著者Kramer, J.S, Pogoryelov, D, Hiesinger, K, Proschak, E.
登録日2018-08-23
公開日2019-07-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Computer-Aided Selective Optimization of Side Activities of Talinolol.
Acs Med.Chem.Lett., 10, 2019
4DMF
DownloadVisualize
BU of 4dmf by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the H177A mutation
分子名称: Putative hydrolase
著者Bahl, C.D, Madden, D.R.
登録日2012-02-07
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Angew.Chem.Int.Ed.Engl., 54, 2015
3KDA
DownloadVisualize
BU of 3kda by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the H269A mutation
分子名称: CFTR inhibitory factor (Cif)
著者Bahl, C.D, Madden, D.R.
登録日2009-10-22
公開日2010-01-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor.
J.Bacteriol., 192, 2010
3KD2
DownloadVisualize
BU of 3kd2 by Molmil
Crystal structure of the CFTR inhibitory factor Cif
分子名称: CFTR inhibitory factor (Cif)
著者Bahl, C.D, Madden, D.R.
登録日2009-10-22
公開日2010-01-26
最終更新日2011-10-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor.
J.Bacteriol., 192, 2010
5HKA
DownloadVisualize
BU of 5hka by Molmil
Crystal structure of the CFTR inhibitory factor Cif bound to an amide inhibitor
分子名称: 5'-[2,6-dichloro-4-(propanoylamino)phenoxy]-2'-hydroxybiphenyl-4-carboxamide, CFTR inhibitory factor
著者Hvorecny, K.L, Madden, D.R.
登録日2016-01-13
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa.
J.Med.Chem., 59, 2016
5HK9
DownloadVisualize
BU of 5hk9 by Molmil
Crystal structure of the CFTR inhibitory factor Cif bound to a urea inhibitor
分子名称: CFTR inhibitory factor, N-(4-{[4'-(carbamoylamino)-6-hydroxybiphenyl-3-yl]oxy}-3,5-dichlorophenyl)propanamide
著者Hvorecny, K.L, Madden, D.R.
登録日2016-01-13
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa.
J.Med.Chem., 59, 2016
5HKB
DownloadVisualize
BU of 5hkb by Molmil
Crystal structure of the CFTR inhibitory factor Cif bound to the inhibitor KB2115
分子名称: ACETATE ION, CFTR Inhibitory Factor (Cif), KB2115
著者Hvorecny, K.L, Madden, D.R.
登録日2016-01-13
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa.
J.Med.Chem., 59, 2016
8GJR
DownloadVisualize
BU of 8gjr by Molmil
Crystal Structure of Nanobody VHH114 Bound to Its Antigen PA14 Cif
分子名称: CFTR inhibitory factor, CITRATE ANION, Nanobody VHH114
著者Simard, A.R, Madden, D.R.
登録日2023-03-16
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of Nanobody VHH114 Bound to Its Antigen PA14 Cif
To Be Published
4DMK
DownloadVisualize
BU of 4dmk by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the Y239F mutation
分子名称: GLYCEROL, Putative hydrolase
著者Bahl, C.D, Madden, D.R.
登録日2012-02-07
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Angew.Chem.Int.Ed.Engl., 54, 2015
4DM7
DownloadVisualize
BU of 4dm7 by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the E153D mutation
分子名称: Putative hydrolase
著者Bahl, C.D, Madden, D.R.
登録日2012-02-07
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Angew.Chem.Int.Ed.Engl., 54, 2015
4DLN
DownloadVisualize
BU of 4dln by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the D129S mutation
分子名称: Putative hydrolase
著者Bahl, C.D, Amacher, J.F, Madden, D.R.
登録日2012-02-06
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Angew.Chem.Int.Ed.Engl., 54, 2015
4DNO
DownloadVisualize
BU of 4dno by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation adducted with the 1,2-epoxyhexane hydrolysis intermediate
分子名称: (2R)-hexane-1,2-diol, Putative hydrolase
著者Bahl, C.D, Patankar, Y.R, Madden, D.R.
登録日2012-02-08
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.
Biochemistry, 55, 2016
4DNF
DownloadVisualize
BU of 4dnf by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation adducted with the epibromohydrin hydrolysis intermediate
分子名称: (2S)-1-bromopropan-2-ol, Putative hydrolase
著者Bahl, C.D, Madden, D.R.
登録日2012-02-08
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.
Biochemistry, 55, 2016
4DMH
DownloadVisualize
BU of 4dmh by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the H207A mutation
分子名称: GLYCEROL, Putative hydrolase
著者Bahl, C.D, Madden, D.R.
登録日2012-02-07
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Angew.Chem.Int.Ed.Engl., 54, 2015
4DMC
DownloadVisualize
BU of 4dmc by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation
分子名称: Putative hydrolase
著者Bahl, C.D, Madden, D.R.
登録日2012-02-07
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.
Biochemistry, 55, 2016
4EUS
DownloadVisualize
BU of 4eus by Molmil
Crystal structure of the CFTR inhibitory factor Cif bound to 1,2-hexanediol
分子名称: (2S)-hexane-1,2-diol, Putative hydrolase
著者Bahl, C.D, Madden, D.R.
登録日2012-04-25
公開日2013-08-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.
Biochemistry, 55, 2016
4EHB
DownloadVisualize
BU of 4ehb by Molmil
Crystal structure of the CFTR inhibitory factor Cif with the D129S mutation bound to epoxyhexane
分子名称: (2R)-2-butyloxirane, Putative hydrolase
著者Hvorecny, K.L, Bahl, C.D, Madden, D.R.
登録日2012-04-02
公開日2013-08-07
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.
Biochemistry, 55, 2016
5TNF
DownloadVisualize
BU of 5tnf by Molmil
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 19,20-EpDPE hydrolysis intermediate
分子名称: (4Z,7Z,10Z,13Z,16Z,19R,20R)-19,20-dihydroxydocosa-4,7,10,13,16-pentaenoic acid, CFTR inhibitory factor
著者Hvorecny, K.L, Madden, D.R.
登録日2016-10-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
5TNQ
DownloadVisualize
BU of 5tnq by Molmil
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (R)-Styrene oxide hydrolysis intermediate
分子名称: (1R)-1-phenylethane-1,2-diol, CFTR inhibitory factor
著者Hvorecny, K.L, Madden, D.R.
登録日2016-10-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
5TNH
DownloadVisualize
BU of 5tnh by Molmil
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 17,18-EpETE hydrolysis intermediate
分子名称: (5Z,8Z,11Z,14Z,17R,18R)-17,18-dihydroxyicosa-5,8,11,14-tetraenoic acid, CFTR inhibitory factor
著者Hvorecny, K.L, Madden, D.R.
登録日2016-10-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
5TNS
DownloadVisualize
BU of 5tns by Molmil
Crystal structure of the D129S mutant of the CFTR inhibitory factor Cif containing 1,2-Epoxycyclohexane
分子名称: (1R,6S)-7-oxabicyclo[4.1.0]heptane, CFTR inhibitory factor
著者Hvorecny, K.L, Madden, D.R.
登録日2016-10-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
5TNM
DownloadVisualize
BU of 5tnm by Molmil
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (R)-1,2-Epoxyoctane hydrolysis intermediate
分子名称: (2R)-octane-1,2-diol, CFTR inhibitory factor
著者Hvorecny, K.L, Madden, D.R.
登録日2016-10-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017
5TNE
DownloadVisualize
BU of 5tne by Molmil
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted cis-Stilbene Oxide hydrolysis intermediate
分子名称: (1R,2R)-1,2-diphenylethane-1,2-diol, CFTR inhibitory factor
著者Hvorecny, K.L, Madden, D.R.
登録日2016-10-14
公開日2017-10-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Structure, 25, 2017

222926

件を2024-07-24に公開中

PDB statisticsPDBj update infoContact PDBjnumon