5HKA
Crystal structure of the CFTR inhibitory factor Cif bound to an amide inhibitor
Summary for 5HKA
| Entry DOI | 10.2210/pdb5hka/pdb |
| Related | 3KD2 4YX9 5HK9 5HKB |
| Descriptor | CFTR inhibitory factor, 5'-[2,6-dichloro-4-(propanoylamino)phenoxy]-2'-hydroxybiphenyl-4-carboxamide (3 entities in total) |
| Functional Keywords | bacterial epoxide hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Pseudomonas aeruginosa (strain UCBPP-PA14) |
| Total number of polymer chains | 4 |
| Total formula weight | 138439.98 |
| Authors | Hvorecny, K.L.,Madden, D.R. (deposition date: 2016-01-13, release date: 2016-05-18, Last modification date: 2023-09-27) |
| Primary citation | Kitamura, S.,Hvorecny, K.L.,Niu, J.,Hammock, B.D.,Madden, D.R.,Morisseau, C. Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa. J.Med.Chem., 59:4790-4799, 2016 Cited by PubMed: 27120257DOI: 10.1021/acs.jmedchem.6b00173 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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