5HKB

Crystal structure of the CFTR inhibitory factor Cif bound to the inhibitor KB2115

Summary for 5HKB

Entry DOI	10.2210/pdb5hkb/pdb
Related	3KD2 4YX9 5HK9 5HKA
Descriptor	CFTR Inhibitory Factor (Cif), KB2115, ACETATE ION, ... (4 entities in total)
Functional Keywords	bacterial epoxide hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Pseudomonas aeruginosa UCBPP-PA14
Total number of polymer chains	4
Total formula weight	138843.53
Authors	Hvorecny, K.L.,Madden, D.R. (deposition date: 2016-01-13, release date: 2016-05-18, Last modification date: 2023-09-27)
Primary citation	Kitamura, S.,Hvorecny, K.L.,Niu, J.,Hammock, B.D.,Madden, D.R.,Morisseau, C. Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa. J.Med.Chem., 59:4790-4799, 2016 Cited by PubMed: 27120257 DOI: 10.1021/acs.jmedchem.6b00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation