5HKB

Crystal structure of the CFTR inhibitory factor Cif bound to the inhibitor KB2115

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004301	molecular_function	epoxide hydrolase activity
A	0005576	cellular_component	extracellular region
A	0043657	cellular_component	host cell
B	0004301	molecular_function	epoxide hydrolase activity
B	0005576	cellular_component	extracellular region
B	0043657	cellular_component	host cell
C	0004301	molecular_function	epoxide hydrolase activity
C	0005576	cellular_component	extracellular region
C	0043657	cellular_component	host cell
D	0004301	molecular_function	epoxide hydrolase activity
D	0005576	cellular_component	extracellular region
D	0043657	cellular_component	host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 64L A 401

Chain	Residue
A	GLU153
A	MET272
A	PHE275
A	HIS297
A	ACT402
A	HOH506
A	ARG163
A	PHE164
A	PRO165
A	LEU174
A	VAL175
A	HIS177
A	GLY270
A	GLY271

---

site_id	AC2
Number of Residues	6
Details	binding site for residue ACT A 402

Chain	Residue
A	ASP129
A	TRP133
A	HIS177
A	PHE178
A	TYR239
A	64L401

---

site_id	AC3
Number of Residues	11
Details	binding site for residue 64L B 401

Chain	Residue
B	GLU153
B	PHE164
B	LEU174
B	VAL175
B	GLY270
B	GLY271
B	MET272
B	PHE275
B	HIS297
B	ACT402
B	HOH718

---

site_id	AC4
Number of Residues	5
Details	binding site for residue ACT B 402

Chain	Residue
B	ASP129
B	HIS177
B	PHE178
B	TYR239
B	64L401

---

site_id	AC5
Number of Residues	14
Details	binding site for residue 64L C 401

Chain	Residue
C	GLU153
C	PHE164
C	PRO165
C	LEU174
C	VAL175
C	HIS177
C	GLY270
C	GLY271
C	MET272
C	PHE275
C	HIS297
C	ACT402
C	HOH535
C	HOH552

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ACT C 402

Chain	Residue
C	ASP129
C	TRP133
C	HIS177
C	TYR239
C	64L401

---

site_id	AC7
Number of Residues	12
Details	binding site for residue 64L D 401

Chain	Residue
D	GLU153
D	PHE164
D	LEU174
D	VAL175
D	HIS177
D	GLY270
D	GLY271
D	MET272
D	PHE275
D	HIS297
D	HOH511
D	HOH687

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ACT D 402

Chain	Residue
D	ASP129
D	HIS177
D	PHE178
D	TYR239

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	440
Details	Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile; hydroxyalkyl-enzyme intermediate","evidences":[{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27980032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4DNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27980032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392259","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EUS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---