4DNO
Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation adducted with the 1,2-epoxyhexane hydrolysis intermediate
Summary for 4DNO
Entry DOI | 10.2210/pdb4dno/pdb |
Related | 3KD2 3KDA 3PI6 4DLN 4DM7 4DMC 4DMF 4DMH 4DNF |
Descriptor | Putative hydrolase, (2R)-hexane-1,2-diol (3 entities in total) |
Functional Keywords | alpha beta hydrolase, epoxide hydrolase covalently adducted with the 1, 2-epoxyhexane hydrolysis intermediate, secreted, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 4 |
Total formula weight | 137127.56 |
Authors | Bahl, C.D.,Patankar, Y.R.,Madden, D.R. (deposition date: 2012-02-08, release date: 2013-08-07, Last modification date: 2023-09-13) |
Primary citation | Bahl, C.D.,Hvorecny, K.L.,Morisseau, C.,Gerber, S.A.,Madden, D.R. Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry, 55:788-797, 2016 Cited by PubMed: 26752215DOI: 10.1021/acs.biochem.5b01229 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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