7B8B
 
 | | ADPG2 - ENDOPOLYGALACTURONASE FROM ARABIDOPSIS THALIANA | | 分子名称: | PHOSPHATE ION, Polygalacturonase ADPG2 | | 著者 | Safran, J, Tabi, W, Habrylo, O, Bouckaert, J, Lefebvre, V, Senechal, F, Pelloux, J. | | 登録日 | 2020-12-12 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Plant polygalacturonase structures specify enzyme dynamics and processivities to fine-tune cell wall pectins.
Plant Cell, 2023
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8TZG
 | | Structure of C-terminal LRRK2 bound to MLi-2 (I2020T mutant) | | 分子名称: | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... | | 著者 | Sanz-Murillo, M, Villagran-Suarez, A, Alegrio Louro, J, Leschziner, A. | | 登録日 | 2023-08-26 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sci Adv, 9, 2023
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8TZH
 | | Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant) | | 分子名称: | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, E11 DARPin, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Sanz-Murillo, M, Villagran-Suarez, A, Alegrio Louro, J, Leschziner, A. | | 登録日 | 2023-08-26 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sci Adv, 9, 2023
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6PEK
 | | Structure of Spastin Hexamer (Subunit A-E) in complex with substrate peptide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | | 登録日 | 2019-06-20 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
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6PEN
 | | Structure of Spastin Hexamer (whole model) in complex with substrate peptide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, EYEYEYEYEY, ... | | 著者 | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | | 登録日 | 2019-06-20 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
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7Z20
 | | 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia and a stalled filamin domain 5 nascent chain | | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Mitropoulou, A, Plessa, E, Wlodarski, T, Ahn, M, Sidhu, H, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J. | | 登録日 | 2022-02-25 | | 公開日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | Modulating co-translational protein folding by rational design and ribosome engineering.
Nat Commun, 13, 2022
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6Y6S
 | | Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8 | | 分子名称: | (1~{R},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Deane, J.E, McLoughlin, J. | | 登録日 | 2020-02-27 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Bicyclic Form of galacto -Noeurostegine Is a Potent Inhibitor of beta-Galactocerebrosidase.
Acs Med.Chem.Lett., 12, 2021
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6Y6T
 | | Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 4.6 | | 分子名称: | (1~{R},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Deane, J.E, McLoughlin, J. | | 登録日 | 2020-02-27 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The Bicyclic Form of galacto -Noeurostegine Is a Potent Inhibitor of beta-Galactocerebrosidase.
Acs Med.Chem.Lett., 12, 2021
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2K0F
 | | Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase | | 分子名称: | 19-mer peptide from Myosin light chain kinase, CALCIUM ION, calmodulin | | 著者 | Gsponer, J, Christodoulou, J, Cavalli, A, Bui, J.M, Richter, B, Dobson, C.M, Vendruscolo, M. | | 登録日 | 2008-02-02 | | 公開日 | 2008-06-10 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction
Structure, 16, 2008
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2MEZ
 | | Flexible anchoring of archaeal MBF1 on ribosomes suggests role as recruitment factor | | 分子名称: | Multiprotein Bridging Factor (MBP-like) | | 著者 | Launay, H, Blombarch, F, Camilloni, C, Vendruscolo, M, van des Oost, J, Christodoulou, J. | | 登録日 | 2013-10-03 | | 公開日 | 2014-06-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain.
Biochem.J., 462, 2014
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2K0E
 | | A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction | | 分子名称: | CALCIUM ION, Calmodulin | | 著者 | Gsponer, J, Christodoulou, J, Cavalli, A, Bui, J.M, Richter, B, Dobson, C.M, Vendruscolo, M. | | 登録日 | 2008-02-02 | | 公開日 | 2008-06-10 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction
Structure, 16, 2008
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1GMM
 | | Carbohydrate binding module CBM6 from xylanase U Clostridium thermocellum | | 分子名称: | CALCIUM ION, CBM6, SODIUM ION, ... | | 著者 | Czjzek, M, Mosbah, A, Bolam, D, Allouch, J, Zamboni, V, Henrissat, B, Gilbert, H.J. | | 登録日 | 2001-09-19 | | 公開日 | 2001-11-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Location of the Ligand-Binding Site of Carbohydrate-Binding Modules that Have Evolved from a Common Sequence is not Conserved.
J.Biol.Chem., 276, 2001
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6E8G
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3FRV
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3FRT
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6G4A
 | | FLN5 (full length) | | 分子名称: | Gelation factor | | 著者 | Waudby, C.A, Wlodarski, T, Karyadi, M.-E, Cassaignau, A.M.E, Chan, S.H.S, Wentink, A.S, Schmidt-Engler, J.M, Camilloni, C, Vendruscolo, M, Cabrita, L.D, Christodoulou, J. | | 登録日 | 2018-03-27 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Mapping energy landscapes of a growing filamin domain reveals an intermediate associated with proline isomerization during biosynthesis
To Be Published
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2AAO
 | | Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana | | 分子名称: | CALCIUM ION, Calcium-dependent protein kinase, isoform AK1 | | 著者 | Chandran, V, Stollar, E.J, Lindorff-Larsen, K, Harper, J.F, Chazin, W.J, Dobson, C.M, Luisi, B.F, Christodoulou, J. | | 登録日 | 2005-07-13 | | 公開日 | 2005-12-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition.
J.Mol.Biol., 357, 2006
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4I11
 | | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. | | 分子名称: | Beta-secretase 1, N-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-phenylalanine, ZINC ION | | 著者 | Bowers, B, Xu, Y, Yuan, S, Probst, G.D, Hom, R.K, Chan, W, Konradi, A.W, Sham, H.L, Zhu, Y.L, Beroza, P, Pan, H, Brecht, E, Yao, N, Lougheed, J, Artis, D.R, Tam, D, Bova, M. | | 登録日 | 2012-11-19 | | 公開日 | 2013-03-06 | | 最終更新日 | 2013-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg.Med.Chem.Lett., 23, 2013
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4I0C
 | | The structure of the camelid antibody cAbHuL5 in complex with human lysozyme | | 分子名称: | CHLORIDE ION, GLYCEROL, Lysozyme C, ... | | 著者 | De Genst, E, Chan, P.H, Pardon, E, Kumita, J.R, Christodoulou, J, Menzer, L, Chirgadze, D.Y, Robinson, C.V, Muyldermans, S, Matagne, A, Wyns, L, Dobson, C.M, Dumoulin, M. | | 登録日 | 2012-11-16 | | 公開日 | 2013-10-09 | | 最終更新日 | 2013-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
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2N62
 | | ddFLN5+110 | | 分子名称: | gelation factor, secretion monitor chimera | | 著者 | Cabrita, L.D, Cassaignau, A.M.E, Launay, H.M.M, Waudby, C.A, Camilloni, C, Robertson, A.L, Wang, X, Wlodarski, T, Wentink, A.S, Vendruscolo, M, Dobson, C.M, Christodoulou, J. | | 登録日 | 2015-08-10 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.
Nat.Struct.Mol.Biol., 23, 2016
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2MZ8
 | | Solution NMR structure of Salmonella Typhimurium transcriptional regulator protein Crl | | 分子名称: | Sigma factor-binding protein Crl | | 著者 | Cavaliere, P, Levi-Acobas, F, Monteil, V, Bellalou, J, Mayer, C, Norel, F, Sizun, C. | | 登録日 | 2015-02-07 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Binding interface between the Salmonella sigma (S)/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl.
Sci Rep, 5, 2015
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3C3Q
 | | ALIX Bro1-domain:CHMIP4B co-crystal structure | | 分子名称: | Charged multivesicular body protein 4b peptide, GLYCEROL, Programmed cell death 6-interacting protein | | 著者 | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | | 登録日 | 2008-01-28 | | 公開日 | 2008-06-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3C3R
 | | ALIX BRO1 CHMP4C complex | | 分子名称: | Charged multivesicular body protein 4c peptide, GLYCEROL, Programmed cell death 6-interacting protein | | 著者 | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | | 登録日 | 2008-01-28 | | 公開日 | 2008-06-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3C3O
 | | ALIX Bro1-domain:CHMIP4A co-crystal structure | | 分子名称: | Charged multivesicular body protein 4a peptide, GLYCEROL, Programmed cell death 6-interacting protein | | 著者 | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | | 登録日 | 2008-01-28 | | 公開日 | 2008-06-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3LQ8
 | | Structure of the kinase domain of c-Met bound to XL880 (GSK1363089) | | 分子名称: | Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | | 著者 | Lougheed, J.C, Stout, T.J. | | 登録日 | 2010-02-08 | | 公開日 | 2010-05-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases.
Cancer Res., 69, 2009
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