6Y6S
Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8
Summary for 6Y6S
Entry DOI | 10.2210/pdb6y6s/pdb |
Descriptor | Galactocerebrosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (1~{R},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol, ... (7 entities in total) |
Functional Keywords | inhibitor, hydrolase |
Biological source | Mus musculus (House mouse) |
Total number of polymer chains | 1 |
Total formula weight | 76379.14 |
Authors | Deane, J.E.,McLoughlin, J. (deposition date: 2020-02-27, release date: 2021-01-13, Last modification date: 2024-01-24) |
Primary citation | Viuff, A.,Salamone, S.,McLoughlin, J.,Deane, J.E.,Jensen, H.H. The Bicyclic Form of galacto -Noeurostegine Is a Potent Inhibitor of beta-Galactocerebrosidase. Acs Med.Chem.Lett., 12:56-59, 2021 Cited by PubMed: 33488964DOI: 10.1021/acsmedchemlett.0c00377 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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