6Y6S

Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8

Summary for 6Y6S

• Entry DOI: 10.2210/pdb6y6s/pdb
• Descriptor: Galactocerebrosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (1~{R},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol, ... (7 entities in total)
• Functional Keywords: inhibitor, hydrolase
• Biological source: Mus musculus (House mouse)
• Total number of polymer chains: 1
• Total formula weight: 76379.14

Authors

Deane, J.E.,McLoughlin, J. (deposition date: 2020-02-27, release date: 2021-01-13, Last modification date: 2024-01-24)

• Primary citation: Viuff, A.,Salamone, S.,McLoughlin, J.,Deane, J.E.,Jensen, H.H.; The Bicyclic Form of galacto -Noeurostegine Is a Potent Inhibitor of beta-Galactocerebrosidase.; Acs Med.Chem.Lett., 12:56-59, 2021; PubMed: 33488964; DOI: 10.1021/acsmedchemlett.0c00377

Experimental method

X-RAY DIFFRACTION (2.1 Å)