7ZB5
| Mot1(1-1836):TBP:DNA - post-hydrolysis complex dimer | 分子名称: | DNA (36-MER), Helicase-like protein, Putative tata-box binding protein | 著者 | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | 登録日 | 2022-03-23 | 公開日 | 2023-04-05 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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4YKE
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5DAC
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with DNA | 分子名称: | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), ... | 著者 | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | 登録日 | 2015-08-19 | 公開日 | 2016-03-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | 主引用文献 | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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5DA9
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with the Rad50-binding domain of Mre11 | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Putative double-strand break protein, ... | 著者 | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | 登録日 | 2015-08-19 | 公開日 | 2016-03-02 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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7NI6
| Human ATM kinase with bound ATPyS | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... | 著者 | Stakyte, K, Rotheneder, M, Lammens, K, Bartho, J.D. | 登録日 | 2021-02-11 | 公開日 | 2021-09-01 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7NI5
| Human ATM kinase with bound inhibitor KU-55933 | 分子名称: | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, Serine-protein kinase ATM, ZINC ION | 著者 | Bartho, J.D, Stakyte, K, Rotheneder, M, Lammens, K, Hopfner, K.P. | 登録日 | 2021-02-11 | 公開日 | 2021-09-01 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Molecular basis of human ATM kinase inhibition. Nat.Struct.Mol.Biol., 28, 2021
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4I1R
| Human MALT1 (caspase-IG3) in complex with thioridazine | 分子名称: | 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Schlauderer, F, Lammens, K, Hopfner, K.P. | 登録日 | 2012-11-21 | 公開日 | 2013-08-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase. Angew.Chem.Int.Ed.Engl., 52, 2013
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4I1P
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7ZR1
| Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure) | 分子名称: | DH domain-containing protein, Double-strand break repair protein, FHA domain-containing protein, ... | 著者 | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | 登録日 | 2022-05-03 | 公開日 | 2023-01-11 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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8BAH
| Human Mre11-Nbs1 complex | 分子名称: | Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin | 著者 | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | 登録日 | 2022-10-11 | 公開日 | 2023-01-11 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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6GPG
| Structure of the RIG-I Singleton-Merten syndrome variant C268F | 分子名称: | MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*G)-3'), ... | 著者 | Laessig, C, Lammens, K, Hopfner, K.-P. | 登録日 | 2018-06-05 | 公開日 | 2018-08-08 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | 主引用文献 | Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants. Elife, 7, 2018
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6GK2
| Helical reconstruction of BCL10 CARD and MALT1 DEATH DOMAIN complex | 分子名称: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Schlauderer, F, Desfosses, A, Gutsche, I, Hopfner, K.P, Lammens, K. | 登録日 | 2018-05-18 | 公開日 | 2018-10-31 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Molecular architecture and regulation of BCL10-MALT1 filaments. Nat Commun, 9, 2018
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6SKY
| FAT and kinase domain of CtTel1 | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | 著者 | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | 登録日 | 2019-08-16 | 公開日 | 2019-10-30 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SL0
| Complete CtTel1 dimer with C2 symmetry | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | 著者 | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | 登録日 | 2019-08-16 | 公開日 | 2019-10-30 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SL1
| Structure of the open conformation of CtTel1 | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | 著者 | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | 登録日 | 2019-08-16 | 公開日 | 2019-10-30 | 最終更新日 | 2020-05-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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6SKZ
| Structure of the closed conformation of CtTel1 | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | 著者 | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | 登録日 | 2019-08-16 | 公開日 | 2019-10-30 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, 28, 2020
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7A08
| CryoEM Structure of cGAS Nucleosome complex | 分子名称: | Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... | 著者 | Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. | 登録日 | 2020-08-07 | 公開日 | 2020-09-23 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 587, 2020
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2XGP
| Yeast DNA polymerase eta in complex with C8-2-acetylaminofluorene containing DNA | 分子名称: | 5'-D(*CP*8FG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ... | 著者 | Scheider, S, Lammens, K, Schorr, S, Hopfner, K.P, Carell, T. | 登録日 | 2010-06-07 | 公開日 | 2010-11-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts. Proc.Natl.Acad.Sci.USA, 107, 2010
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3THN
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3THO
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7ZKE
| Mot1:TBP:DNA - pre-hydrolysis state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (36-MER), ... | 著者 | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | 登録日 | 2022-04-12 | 公開日 | 2023-04-26 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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6RR9
| DNA/RNA binding protein | 分子名称: | GLYCEROL, SULFATE ION, Schlafen family member 5, ... | 著者 | Huber, E, Lammens, K. | 登録日 | 2019-05-17 | 公開日 | 2020-07-08 | 最終更新日 | 2022-01-26 | 実験手法 | X-RAY DIFFRACTION (3.432 Å) | 主引用文献 | Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Res., 2022
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6S6V
| Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS | 分子名称: | MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ... | 著者 | Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P. | 登録日 | 2019-07-03 | 公開日 | 2019-09-04 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol.Cell, 76, 2019
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4HT1
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4ON9
| DECH box helicase domain | 分子名称: | CHLORIDE ION, Probable ATP-dependent RNA helicase DDX58, SULFATE ION | 著者 | Deimling, T, Witte, G, Hopfner, K.P. | 登録日 | 2014-01-28 | 公開日 | 2014-07-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Crystal and solution structure of the human RIG-I SF2 domain Acta Crystallogr.,Sect.F, 70, 2014
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