5T9J
 
 | | Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface | | 分子名称: | DNA (5'-D(*DAP*DCP*DGP*DAP*DTP*DGP*DGP*DAP*DGP*DCP*DCP*DGP*DCP*DTP*DAP*DGP*DGP*DCP*DTP*DC)-3'), DNA (5'-D(*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DAP*DGP*DGP*DGP*DAP*DTP*DGP*DC)-3'), DNA (5'-D(*DGP*DAP*DGP*DCP*DCP*DTP*DAP*DGP*DCP*DGP*DTP*DCP*DCP*DGP*DGP*DAP*DAP*DTP*DTP*DC)-3'), ... | | 著者 | Lee, S.-H, Biertumpfel, C. | | 登録日 | 2016-09-09 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.00012732 Å) | | 主引用文献 | Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Elife, 4, 2015
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2EIP
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5UXH
 | | Structure of Human POFUT1 in complex with GDP-fucose | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GDP-fucose protein O-fucosyltransferase 1, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE | | 著者 | Xu, X, McMillan, B, Blacklow, S.C. | | 登録日 | 2017-02-22 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.
Glycobiology, 27, 2017
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3ZU7
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3ZUV
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5UX6
 | | Structure of Human POFUT1 in its apo form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GDP-fucose protein O-fucosyltransferase 1, GLYCEROL | | 著者 | Xu, X, McMillan, B, Blacklow, S.C. | | 登録日 | 2017-02-22 | | 公開日 | 2017-04-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.
Glycobiology, 27, 2017
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1FAJ
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1YPP
 | | ACID ANHYDRIDE HYDROLASE | | 分子名称: | INORGANIC PYROPHOSPHATASE, MANGANESE (II) ION, PHOSPHATE ION | | 著者 | Harutyunyan, E.H, Kuranova, I.P, Lamzin, V.S, Dauter, Z, Wilson, K.S. | | 登録日 | 1996-05-29 | | 公開日 | 1996-12-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | X-ray structure of yeast inorganic pyrophosphatase complexed with manganese and phosphate.
Eur.J.Biochem., 239, 1996
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4C57
 | | Structure of GAK kinase in complex with a nanobody | | 分子名称: | (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, 1,2-ETHANEDIOL, Cyclin-G-associated kinase, ... | | 著者 | Chaikuad, A, Keates, T, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Muller-Knapp, S. | | 登録日 | 2013-09-10 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structure of Cyclin G-Associated Kinase (Gak) Trapped in Different Conformations Using Nanobodies.
Biochem.J., 459, 2014
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4C58
 | | Structure of GAK kinase in complex with nanobody (NbGAK_4) | | 分子名称: | 1,2-ETHANEDIOL, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, Cyclin-G-associated kinase, ... | | 著者 | Chaikuad, A, Keates, T, Allerston, C.K, Gileadi, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Muller-Knapp, S. | | 登録日 | 2013-09-10 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
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4C59
 | | Structure of GAK kinase in complex with nanobody (NbGAK_4) | | 分子名称: | (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, Cyclin-G-associated kinase, NANOBODY | | 著者 | Chaikuad, A, Keates, T, Allerston, C.K, Gileadi, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Muller-Knapp, S. | | 登録日 | 2013-09-10 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
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6BDZ
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6BE6
 | | ADAM10 Extracellular Domain | | 分子名称: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 10, SULFATE ION, ... | | 著者 | Seegar, T.C.M. | | 登録日 | 2017-10-24 | | 公開日 | 2017-12-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.
Cell, 171, 2017
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6G9P
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5JEA
 | | Structure of a cytoplasmic 11-subunit RNA exosome complex including Ski7, bound to RNA | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Exosome complex component CSL4, Exosome complex component MTR3, ... | | 著者 | Kowalinski, E, Ebert, J, Stegmann, E, Conti, E. | | 登録日 | 2016-04-18 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.
Mol.Cell, 63, 2016
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5JNB
 | | structure of GLD-2/RNP-8 complex | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, Poly(A) RNA polymerase gld-2, ... | | 著者 | Nakel, K, Bonneau, F, Basquin, C, Eckmann, C.R, Conti, E. | | 登録日 | 2016-04-29 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.486 Å) | | 主引用文献 | Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity.
Rna, 22, 2016
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4FP9
 | | Human MTERF4-NSUN4 protein complex | | 分子名称: | S-ADENOSYLMETHIONINE, SULFATE ION, mTERF domain-containing protein 2, ... | | 著者 | Spahr, H, Hallberg, B.M. | | 登録日 | 2012-06-21 | | 公開日 | 2012-09-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6G70
 | | Structure of murine Prpf39 | | 分子名称: | Pre-mRNA-processing factor 39 | | 著者 | De Bortoli, F.D, Loll, B, Wahl, M, Heyd, F. | | 登録日 | 2018-04-04 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.
Nucleic Acids Res., 47, 2019
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6TW2
 | | Re-refined crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor | | 分子名称: | Dual specificity protein kinase CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | | 著者 | Loll, B, Haltenhof, T, Heyd, F, Wahl, M.C. | | 登録日 | 2020-01-12 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression.
Mol.Cell, 78, 2020
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2OO9
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1LDT
 | | COMPLEX OF LEECH-DERIVED TRYPTASE INHIBITOR WITH PORCINE TRYPSIN | | 分子名称: | CALCIUM ION, TRYPSIN, TRYPTASE INHIBITOR | | 著者 | Stubbs, M.T. | | 登録日 | 1997-05-15 | | 公開日 | 1998-05-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.
J.Biol.Chem., 272, 1997
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1H6F
 | | Human TBX3, a transcription factor responsible for ulnar-mammary syndrome, bound to a palindromic DNA site | | 分子名称: | 5'-D(*TP*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP* AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*T)-3', MAGNESIUM ION, T-BOX TRANSCRIPTION FACTOR TBX3 | | 著者 | Coll, M, Muller, C.W. | | 登録日 | 2001-06-13 | | 公開日 | 2002-04-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of the DNA-Bound T-Box Domain of Human Tbx3, a Transcription Factor Responsible for Ulnar- Mammary Syndrome
Structure, 10, 2002
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8SOS
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6ZK6
 | | Protein Phosphatase 1 (PP1) T320E mutant | | 分子名称: | FE (III) ION, MANGANESE (II) ION, PHOSPHATE ION, ... | | 著者 | Salvi, F, Barabas, O, Koehn, M. | | 登録日 | 2020-06-29 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Towards Dissecting the Mechanism of Protein Phosphatase-1 Inhibition by Its C-Terminal Phosphorylation.
Chembiochem, 22, 2021
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6G0I
 | | Active Fe-PP1 | | 分子名称: | FE (III) ION, MANGANESE (II) ION, PHOSPHATE ION, ... | | 著者 | Salvi, F, Barabas, O, Koehn, M. | | 登録日 | 2018-03-18 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Effects of stably incorporated iron on protein phosphatase-1 structure and activity.
FEBS Lett., 592, 2018
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