5T9J

Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface

Summary for 5T9J

• Entry DOI: 10.2210/pdb5t9j/pdb
• Descriptor: Flap endonuclease GEN homolog 1, DNA (5'-D(*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DAP*DGP*DGP*DGP*DAP*DTP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DAP*DTP*DCP*DCP*DCP*DTP*DAP*DAP*DGP*DCP*DTP*DCP*DCP*DAP*DTP*DCP*DGP*DT)-3'), ... (8 entities in total)
• Functional Keywords: protein-dna complex, holliday junction resolvase, structure-specific endonuclease, dna four-way junction, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q17RS7
• Total number of polymer chains: 6
• Total formula weight: 142758.05

Authors

Lee, S.-H.,Biertumpfel, C. (deposition date: 2016-09-09, release date: 2016-09-21)

• Primary citation: Lee, S.H.,Princz, L.N.,Klugel, M.F.,Habermann, B.,Pfander, B.,Biertumpfel, C.; Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.; Elife, 4:-, 2015; PubMed: 26682650; DOI: 10.7554/eLife.12256

Experimental method

X-RAY DIFFRACTION (3.00012743215 Å)