6TW2

Re-refined crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor

Summary for 6TW2

Entry DOI	10.2210/pdb6tw2/pdb
Descriptor	Dual specificity protein kinase CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, tyrosine-protein kinase, nucleus, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40079.66
Authors	Loll, B.,Haltenhof, T.,Heyd, F.,Wahl, M.C. (deposition date: 2020-01-12, release date: 2020-02-05, Last modification date: 2024-01-24)
Primary citation	Haltenhof, T.,Kotte, A.,De Bortoli, F.,Schiefer, S.,Meinke, S.,Emmerichs, A.K.,Petermann, K.K.,Timmermann, B.,Imhof, P.,Franz, A.,Loll, B.,Wahl, M.C.,Preussner, M.,Heyd, F. A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression. Mol.Cell, 78:57-69.e4, 2020 Cited by PubMed: 32059760 DOI: 10.1016/j.molcel.2020.01.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation