8IU0
| Cryo-EM structure of the potassium-selective channelrhodopsin HcKCR1 H225F mutant in lipid nanodisc | 分子名称: | (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, HcKCR1, PALMITIC ACID, ... | 著者 | Tajima, S, Kim, Y, Nakamura, S, Yamashita, K, Fukuda, M, Deisseroth, K, Kato, H.E. | 登録日 | 2023-03-23 | 公開日 | 2023-09-06 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structural basis for ion selectivity in potassium-selective channelrhodopsins. Cell, 186, 2023
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9BQJ
| RO76 bound muOR-Gi1-scFv16 complex structure | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Majumdar, S, Kobilka, B.K. | 登録日 | 2024-05-10 | 公開日 | 2024-09-11 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at mu OR. Acs Cent.Sci., 10, 2024
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8H87
| Cryo-EM structure of the potassium-selective channelrhodopsin HcKCR2 in lipid nanodisc | 分子名称: | (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, HcKCR2, PALMITIC ACID, ... | 著者 | Tajima, S, Kim, Y, Yamashita, K, Fukuda, M, Deisseroth, K, Kato, H.E. | 登録日 | 2022-10-21 | 公開日 | 2023-09-06 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | 主引用文献 | Structural basis for ion selectivity in potassium-selective channelrhodopsins. Cell, 186, 2023
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8H86
| Cryo-EM structure of the potassium-selective channelrhodopsin HcKCR1 in lipid nanodisc | 分子名称: | (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, HcKCR1, PALMITIC ACID, ... | 著者 | Tajima, S, Kim, Y, Yamashita, K, Fukuda, M, Deisseroth, K, Kato, H.E. | 登録日 | 2022-10-21 | 公開日 | 2023-09-06 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | 主引用文献 | Structural basis for ion selectivity in potassium-selective channelrhodopsins. Cell, 186, 2023
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8FX5
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline | 分子名称: | Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2023-01-23 | 公開日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR. Nat Commun, 14, 2023
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8GHV
| Cannabinoid Receptor 1-G Protein Complex | 分子名称: | (5Z,8Z,11Z,13S,14Z)-N-[(2R)-1-hydroxypropan-2-yl]-13-methylicosa-5,8,11,14-tetraenamide, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Krishna Kumar, K, Robertson, M.J, Skiniotis, G, Kobilka, B.K. | 登録日 | 2023-03-12 | 公開日 | 2023-05-24 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for activation of CB1 by an endocannabinoid analog. Nat Commun, 14, 2023
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7TB3
| cryo-EM structure of MBP-KIX-apoferritin | 分子名称: | Isoform 2 of CREB-binding protein,Ferritin heavy chain, N-terminally processed | 著者 | Zhang, K, Horikoshi, N, Li, S, Powers, A, Hameedi, M, Pintilie, G, Chae, H, Khan, Y, Suomivuori, C, Dror, R, Sakamoto, K, Chiu, W, Wakatsuki, S. | 登録日 | 2021-12-21 | 公開日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | 主引用文献 | Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. Acs Cent.Sci., 8, 2022
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7TBH
| cryo-EM structure of MBP-KIX-apoferritin complex with peptide 7 | 分子名称: | Isoform 2 of CREB-binding protein,Ferritin heavy chain, N-terminally processed, LEU-SER-ARG-ARG-PRO-SEP-TYR-ARG-LYS-ILE-LEU-ASN-ASP-LEU-SER-SER-ASP-ALA-PRO | 著者 | Zhang, K, Horikoshi, N, Li, S, Powers, A, Hameedi, M, Pintilie, G, Chae, H, Khan, Y, Suomivuori, C, Dror, R, Sakamoto, K, Chiu, W, Wakatsuki, S. | 登録日 | 2021-12-22 | 公開日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. Acs Cent.Sci., 8, 2022
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6CSM
| Crystal structure of the natural light-gated anion channel GtACR1 | 分子名称: | GtACR1, OLEIC ACID, RETINAL | 著者 | Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K. | 登録日 | 2018-03-21 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature, 561, 2018
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6CSN
| Crystal structure of the designed light-gated anion channel iC++ at pH8.5 | 分子名称: | CHLORIDE ION, OLEIC ACID, RETINAL, ... | 著者 | Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K. | 登録日 | 2018-03-21 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature, 561, 2018
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6CSO
| Crystal structure of the designed light-gated anion channel iC++ at pH6.5 | 分子名称: | OLEIC ACID, RETINAL, iC++ | 著者 | Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K. | 登録日 | 2018-03-21 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature, 561, 2018
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7N98
| Cryo-EM structure of MFSD2A | 分子名称: | Sodium-dependent lysophosphatidylcholine symporter 1 | 著者 | Zhang, J, Feng, L. | 登録日 | 2021-06-17 | 公開日 | 2021-08-04 | 最終更新日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A. Nature, 596, 2021
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6N4B
| Cannabinoid Receptor 1-G Protein Complex | 分子名称: | CHOLESTEROL, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Krishna Kumar, K, Shalev-Benami, M, Hu, H, Weis, W.I, Kobilka, B.K, Skiniotis, G. | 登録日 | 2018-11-18 | 公開日 | 2019-01-30 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell, 176, 2019
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7W9W
| 2.02 angstrom cryo-EM structure of the pump-like channelrhodopsin ChRmine | 分子名称: | CHOLESTEROL, ChRmine, PALMITIC ACID, ... | 著者 | Kishi, K.E, Kim, Y, Fukuda, M, Yamashita, K, Deisseroth, K, Kato, H.E. | 登録日 | 2021-12-11 | 公開日 | 2022-02-02 | 最終更新日 | 2022-03-09 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine. Cell, 185, 2022
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4XT3
| Structure of a viral GPCR bound to human chemokine CX3CL1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fractalkine, G-protein coupled receptor homolog US28, ... | 著者 | Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. | 登録日 | 2015-01-22 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.801 Å) | 主引用文献 | Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science, 347, 2015
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4XT1
| Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Fractalkine, ... | 著者 | Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. | 登録日 | 2015-01-22 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.886 Å) | 主引用文献 | Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science, 347, 2015
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7YIT
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8E0G
| Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aS,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indole-1,10-diol, CHOLESTEROL, ... | 著者 | Munro, T.A. | 登録日 | 2022-08-09 | 公開日 | 2023-10-18 | 最終更新日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol., 21, 2023
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5TCX
| Crystal structure of human tetraspanin CD81 | 分子名称: | CD81 antigen, CHOLESTEROL | 著者 | Zimmerman, B, McMillan, B.J, Seegar, T.C.M, Kruse, A.C, Blacklow, S.C. | 登録日 | 2016-09-16 | 公開日 | 2016-11-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.955 Å) | 主引用文献 | Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell, 167, 2016
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5UHS
| Structure of a SemiSWEET D57A mutant | 分子名称: | MONOVACCENIN, Sugar transporter SemiSWEET, beta-D-glucopyranose | 著者 | Fastman, N.M, Feng, L. | 登録日 | 2017-01-11 | 公開日 | 2017-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mechanism of Substrate Translocation in an Alternating Access Transporter. Cell, 169, 2017
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5UHQ
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6DDE
| Mu Opioid Receptor-Gi Protein Complex | 分子名称: | DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I. | 登録日 | 2018-05-10 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the mu-opioid receptor-Giprotein complex. Nature, 558, 2018
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6DK1
| Human sigma-1 receptor bound to (+)-pentazocine | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,6S,11S)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol, GLYCEROL, ... | 著者 | Schmidt, H.R, Kruse, A.C. | 登録日 | 2018-05-28 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Structural basis for sigma1receptor ligand recognition. Nat. Struct. Mol. Biol., 25, 2018
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6DDF
| Mu Opioid Receptor-Gi Protein Complex | 分子名称: | DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Koehl, A, Hu, H, Maeda, S, Manglik, A, Kobilka, B.K, Skiniotis, G, Weis, W.I. | 登録日 | 2018-05-10 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the mu-opioid receptor-Giprotein complex. Nature, 558, 2018
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6DK0
| Human sigma-1 receptor bound to NE-100 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLYCEROL, N-{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}-N-propylpropan-1-amine, ... | 著者 | Schmidt, H.R, Kruse, A.C. | 登録日 | 2018-05-28 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for sigma1receptor ligand recognition. Nat. Struct. Mol. Biol., 25, 2018
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