9B65

Biased agonist bound CB1-Gi structure

Summary for 9B65

• Entry DOI: 10.2210/pdb9b65/pdb
• EMDB information: 44247
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g protein-coupled receptor (gpcr), g protein, gi, biased ligand, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 169808.15

Authors

Rangari, V.A.,O'Brien, E.S.,Kobilka, B.K.,Krishna Kumar, K.,Majumdar, S. (deposition date: 2024-03-23, release date: 2025-03-05)

• Primary citation: Rangari, V.A.,O'Brien, E.S.,Powers, A.S.,Slivicki, R.,Bertels, Z.,Appourchaux, K.,Aydin, D.,Ramos-Gonzalez, N.,Mwirigi, J.,Lin, L.,Mangutov, E.,Sobecks, B.L.,Awad-Agbaria, Y.,Uphade, M.B.,Aguilar, J.,Peddada, T.N.,Shiimura, Y.,Huang, X.-P.,Folarin-Hines, J.,Payne, M.,Kalathil, A.,Varga, B.R.,Kobilka, B.K.,Pradhan, A.A.,Cameron, M.D.,Kumar, K.K.,Dror, R.O.,Gereau, R.W.,Majumdar, S.; A cryptic pocket in CB1 drives peripheral and functional selectivity; Nature, 2025; DOI: 10.1038/s41586-025-08618-7

Experimental method

ELECTRON MICROSCOPY (3.03 Å)