8F86
 
 | | SIRT6 bound to an H3K9Ac nucleosome | | 分子名称: | DNA (148-MER), Histone H2A type 1, Histone H2B, ... | | 著者 | Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. | | 登録日 | 2022-11-21 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
J.Am.Chem.Soc., 145, 2023
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5KJ2
 | | The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer | | 分子名称: | Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION | | 著者 | Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. | | 登録日 | 2016-06-17 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature, 550, 2017
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7LJE
 | | Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases | | 分子名称: | 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide, Histone acetyltransferase p300 | | 著者 | Jakob, C.G. | | 登録日 | 2021-01-29 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.607 Å) | | 主引用文献 | Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.
Bioorg.Med.Chem.Lett., 39, 2021
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8Q1H
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8Q1G
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8Q1J
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6NCT
 | | Structure of p110alpha/niSH2 - vector data collection | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, SULFATE ION, ... | | 著者 | Miller, M.S, Maheshwari, S, Amzel, L.M, Gabelli, S.B. | | 登録日 | 2018-12-12 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.
Molecules, 24, 2019
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6NCK
 | | Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM) | | 分子名称: | COPPER (II) ION, NICKEL (II) ION, Peptidyl-glycine alpha-amidating monooxygenase | | 著者 | Miller, M.S, Maheshwari, S, Gabelli, S.B. | | 登録日 | 2018-12-11 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.
Molecules, 24, 2019
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6NCI
 | | Crystal structure of CDP-Chase: Vector data collection | | 分子名称: | D-ribose, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | | 著者 | Miller, M.S, Shi, W, Gabelli, S.B. | | 登録日 | 2018-12-11 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.
Molecules, 24, 2019
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6NCH
 | | Crystal structure of CDP-Chase: Raster data collection | | 分子名称: | D-ribose, PHOSPHATE ION, Phosphohydrolase (MutT/nudix family protein), ... | | 著者 | Miller, M.S, Shi, W, Gabelli, S.B. | | 登録日 | 2018-12-11 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.
Molecules, 24, 2019
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3Q35
 | | Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation | | 分子名称: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, Histone acetyltransferase, ... | | 著者 | Tang, Y, Yuan, H, Meeth, K, Marmorstein, R. | | 登録日 | 2010-12-21 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation.
Structure, 19, 2011
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3Q33
 | | Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation | | 分子名称: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, HISTONE H3, ... | | 著者 | Tang, Y, Yuan, H, Meeth, K, Marmorstein, R. | | 登録日 | 2010-12-21 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation.
Structure, 19, 2011
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5LY1
 | | JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND Macrocyclic PEPTIDE Inhibitor CP2 (13-mer) | | 分子名称: | CHLORIDE ION, CP2, GLYCEROL, ... | | 著者 | King, O.N.F, Chowdhury, R, Kawamura, A, Schofield, C.J. | | 登録日 | 2016-09-23 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
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5LY2
 | | JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Macrocyclic PEPTIDE Inhibitor CP2_R6Kme3 (13-mer) | | 分子名称: | CHLORIDE ION, CP2_R6Kme3, GLYCEROL, ... | | 著者 | Chowdhury, R, Madden, S.K, Hopkinson, R, Schofield, C.J. | | 登録日 | 2016-09-23 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
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3QM0
 | | Crystal structure of RTT109-AC-CoA complex | | 分子名称: | ACETYL COENZYME *A, Histone acetyltransferase RTT109, MERCURY (II) ION | | 著者 | Tang, Y, Marmorstein, R. | | 登録日 | 2011-02-03 | | 公開日 | 2011-02-16 | | 最終更新日 | 2017-08-02 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.
Nat.Struct.Mol.Biol., 15, 2008
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3BCE
 | | Crystal structure of the ErbB4 kinase | | 分子名称: | DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, Receptor tyrosine-protein kinase erbB-4, ... | | 著者 | Qiu, C. | | 登録日 | 2007-11-12 | | 公開日 | 2008-02-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
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3BBW
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3BBT
 | | crystal structure of the ErbB4 kinase in complex with lapatinib | | 分子名称: | N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, Receptor tyrosine-protein kinase erbB-4 | | 著者 | Qiu, C. | | 登録日 | 2007-11-11 | | 公開日 | 2008-02-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
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5TJ7
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5TJQ
 | | Structure of WWP2 2,3-linker-HECT | | 分子名称: | NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2 | | 著者 | Chen, Z, Gabelli, S.B. | | 登録日 | 2016-10-04 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
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5TJ8
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2G2H
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2G2F
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2G1T
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2G2I
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