2G2F

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Summary for 2G2F

DescriptorAbl Kinase, ATP-Peptide Conjugate, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywordsprotein kinase, transferase
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor P00519
Total number of polymer chains3
Total molecular weight68661.88
Authors
Levinson, N.M.,Kuchment, O. (deposition date: 2006-02-15, release date: 2006-05-23, Last modification date: 2012-03-07)
Primary citation
Levinson, N.M.,Kuchment, O.,Shen, K.,Young, M.A.,Koldobskiy, M.,Karplus, M.,Cole, P.A.,Kuriyan, J.
A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4:753-767, 2006
PubMed: 16640460 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pbio.0040144
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.283171.5%4.4%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2g2f
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Molmil generated image of 2g2f
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Molmil generated image of 2g2f
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2g2f
no rotation
Molmil generated image of 2g2f
rotated about x axis by 90°
Molmil generated image of 2g2f
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2g2f.pdb2.gz [46.99 KB])
Coordinate files for Biological unit (2g2f.pdb1.gz [49.9 KB])