2G2F
A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Abl Kinase | polymer | 287 | 33182.0 | 2 | UniProt (P00519) Pfam (PF07714) In PDB | Homo sapiens (human) | p150, c- ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | C | ATP-Peptide Conjugate | polymer | 11 | 1194.4 | 1 | |||
| 3 | B | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 1 | Chemie (AGS) | |||
| 4 | C | THIOPHOSPHORIC ACID O-((ADENOSYL-PHOSPHO)PHOSPHO)-S-ACETAMIDYL-DIESTER | non-polymer | 580.3 | 1 | Chemie (112) | |||
| 5 | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 512 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 226 | - | cloning artifact |
| His 227 | - | cloning artifact |
| Met 228 | - | cloning artifact |
| Pro 396 | His 396 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 67558.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1103.5 | |
| All* | Total formula weight | 68661.9 |
