5LY1
JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND Macrocyclic PEPTIDE Inhibitor CP2 (13-mer)
Summary for 5LY1
Entry DOI | 10.2210/pdb5ly1/pdb |
Related | 2OX0 2YBP 4AI9 4BIS 4V2V 5LY2 |
Descriptor | Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ... (8 entities in total) |
Functional Keywords | jmjd2a, kdm4a, oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, double-stranded beta helix, dsbh, facial triad, demethylase, histone, jmjc domain, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O75164 |
Total number of polymer chains | 5 |
Total formula weight | 180504.67 |
Authors | King, O.N.F.,Chowdhury, R.,Kawamura, A.,Schofield, C.J. (deposition date: 2016-09-23, release date: 2017-04-12, Last modification date: 2024-01-17) |
Primary citation | Kawamura, A.,Munzel, M.,Kojima, T.,Yapp, C.,Bhushan, B.,Goto, Y.,Tumber, A.,Katoh, T.,King, O.N.,Passioura, T.,Walport, L.J.,Hatch, S.B.,Madden, S.,Muller, S.,Brennan, P.E.,Chowdhury, R.,Hopkinson, R.J.,Suga, H.,Schofield, C.J. Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nat Commun, 8:14773-14773, 2017 Cited by PubMed: 28382930DOI: 10.1038/ncomms14773 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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