1ONG
| SHV-1 beta-lactamase with a penem inhibitor | 分子名称: | 7-(5,6-DIHYDRO-8H-IMIDAZO[2,1-C][1,4]OXAZIN-2-YL)-6-FORMYL-2,7-DIHYDRO- [1,4]THIAZEPINE-3-CARBOXYLIC ACID, BETA-LACTAMASE SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Nukaga, M, Mayama, K, Bonomo, R.A, Knox, J.R. | 登録日 | 2003-02-27 | 公開日 | 2003-12-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Inhibition of Class A and Class C Beta-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate Biochemistry, 42, 2003
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1N9B
| Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BETA-LACTAMASE SHV-2, ... | 著者 | Nukaga, M, Mayama, K, Hujer, A.M, Bonomo, R.A, Knox, J.R. | 登録日 | 2002-11-22 | 公開日 | 2003-04-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | 主引用文献 | Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme J.Mol.Biol., 328, 2003
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1RCJ
| Crystal structure of E166A mutant of SHV-1 beta-lactamase with the trans-enamine intermediate of tazobactam | 分子名称: | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, TAZOBACTAM TRANS-ENAMINE INTERMEDIATE | 著者 | Padayatti, P.S, Helfand, M.S, Totir, M.A, Carey, M.P, Hujer, A.M, Carey, P.R, Bonomo, R.A, van den Akker, F. | 登録日 | 2003-11-04 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Tazobactam Forms a Stoichiometric trans-Enamine Intermediate in the E166A Variant of SHV-1 beta-Lactamase: 1.63 A Crystal Structure Biochemistry, 43, 2004
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8EHH
| Crystal structure of the class A extended-spectrum beta-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution | 分子名称: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Power, P, Ghiglione, B, Bonomo, R.A, Rodriguez, M.M, Gutkind, G, Klinke, S. | 登録日 | 2022-09-14 | 公開日 | 2023-09-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Biochemical and structural evidences of the activity of relebactam as inhibitor of the extended-spectrum beta-lactamase CTX-M-96. To be published
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3N4I
| Crystal structure of the SHV-1 D104E beta-lactamase/beta-lactamase inhibitor protein (BLIP) complex | 分子名称: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein | 著者 | Hanes, M.S, Reynolds, K.A, McNamara, C, Ghosh, P, Bonomo, R.A, Kirsch, J.F, Handel, T.M. | 登録日 | 2010-05-21 | 公開日 | 2011-03-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Specificity and Cooperativity at beta-lactamase Position 104 in TEM-1/BLIP and SHV-1/BLIP interactions Proteins, 79, 2011
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6BN3
| CTX-M-151 class A extended-spectrum beta-lactamase apo crystal structure at 1.3 Angstrom resolution | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase | 著者 | Power, P, Ghiglione, B, Rodriguez, M.M, Gutkind, G, Ishii, Y, Bonomo, R.A, Klinke, S. | 登録日 | 2017-11-16 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.278 Å) | 主引用文献 | Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam. Antimicrob.Agents Chemother., 65, 2021
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6BPF
| CTX-M-151 class A extended-spectrum beta-lactamase crystal structure in complex with avibactam at 1.32 Angstrom resolution | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Power, P, Ghiglione, B, Rodriguez, M.M, Gutkind, G, Ishii, Y, Bonomo, R.A, Klinke, S. | 登録日 | 2017-11-23 | 公開日 | 2018-11-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.318 Å) | 主引用文献 | Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam. Antimicrob.Agents Chemother., 65, 2021
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4NQ2
| Structure of Zn(II)-bound metallo-beta-lactamse VIM-2 from Pseudomonas aeruginosa | 分子名称: | ACETATE ION, Beta-lactamase class B VIM-2, ZINC ION | 著者 | Aitha, M, Nix, J.C, Crowder, M.W, Page, R.C. | 登録日 | 2013-11-23 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-beta-lactamase VIM-2. Biochemistry, 53, 2014
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3ISG
| Structure of the class D beta-lactamase OXA-1 in complex with doripenem | 分子名称: | (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-lactamase OXA-1 | 著者 | Powers, R.A. | 登録日 | 2009-08-25 | 公開日 | 2009-12-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem. Biochemistry, 48, 2009
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4U0X
| Structure of ADC-7 beta-lactamase in complex with boronic acid inhibitor S02030 | 分子名称: | 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, ADC-7 beta-lactamase, PHOSPHATE ION | 著者 | Powers, R.A, Wallar, B.J, Swanson, H.C. | 登録日 | 2014-07-14 | 公開日 | 2014-11-19 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii. Biochemistry, 53, 2014
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4U0T
| Crystal structure of ADC-7 beta-lactamase | 分子名称: | ADC-7 beta-lactamase, PHOSPHATE ION | 著者 | Powers, R.A, Wallar, B.J. | 登録日 | 2014-07-14 | 公開日 | 2014-11-19 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii. Biochemistry, 53, 2014
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4X55
| Structure of the class D Beta-Lactamase OXA-225 K82D in Acyl-Enzyme Complex with Ceftazidime | 分子名称: | 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Beta-lactamase OXA-225 | 著者 | Clasman, J.R, June, C.M, Powers, R.A, Leonard, D.A. | 登録日 | 2014-12-04 | 公開日 | 2015-03-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.941 Å) | 主引用文献 | Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D beta-Lactamases from Acinetobacter baumannii. Biochemistry, 54, 2015
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4X53
| Structure of the class D Beta-Lactamase OXA-160 V130D in Acyl-Enzyme Complex with Aztreonam | 分子名称: | 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, BICARBONATE ION, Class D beta-lactamase OXA-160 | 著者 | Clasman, J.R, June, C.M, Powers, R.A, Leonard, D.A. | 登録日 | 2014-12-04 | 公開日 | 2015-03-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D beta-Lactamases from Acinetobacter baumannii. Biochemistry, 54, 2015
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4X56
| Structure of the class D Beta-Lactamase OXA-160 V130D in Acyl-Enzyme Complex with Ceftazidime | 分子名称: | ACYLATED CEFTAZIDIME, Class D beta-lactamase OXA-160 | 著者 | Clasman, J.R, June, C.M, Powers, R.A, Leonard, D.A. | 登録日 | 2014-12-04 | 公開日 | 2015-03-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D beta-Lactamases from Acinetobacter baumannii. Biochemistry, 54, 2015
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6TZH
| ADC-7 in complex with boronic acid transition state inhibitor S06015 | 分子名称: | Beta-lactamase, GLYCINE, PHOSPHATE ION, ... | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | 登録日 | 2019-08-12 | 公開日 | 2020-06-24 | 最終更新日 | 2020-07-22 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase. Acs Infect Dis., 6, 2020
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6TZJ
| ADC-7 in complex with boronic acid transition state inhibitor ME_096 | 分子名称: | Beta-lactamase, GLYCINE, [4-[[(4-methylphenyl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]methyl-phosphonooxy-borinic acid | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | 登録日 | 2019-08-12 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase. Acs Infect Dis., 6, 2020
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6TZI
| ADC-7 in complex with boronic acid transition state inhibitor PFC_001 | 分子名称: | Beta-lactamase, phosphonooxy-[[4-[[2,2,2-tris(fluoranyl)ethylsulfonylamino]methyl]-1,2,3-triazol-1-yl]methyl]borinic acid | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | 登録日 | 2019-08-12 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.744 Å) | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase. Acs Infect Dis., 6, 2020
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6TZF
| ADC-7 in complex with boronic acid transition state inhibitor S17079 | 分子名称: | 3-(1-{[hydroxy(phosphonooxy)boranyl]methyl}-1H-1,2,3-triazol-4-yl)benzoic acid, Beta-lactamase | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | 登録日 | 2019-08-12 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase. Acs Infect Dis., 6, 2020
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5ZYB
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4FCF
| K234R: apo structure of inhibitor resistant beta-lactamase | 分子名称: | 2-AMINOETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Rodkey, E.A, van den Akker, F. | 登録日 | 2012-05-24 | 公開日 | 2012-12-26 | 最終更新日 | 2013-10-02 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) beta-lactamase. J.Med.Chem., 56, 2013
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4FH4
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4FD8
| Structure of apo S70C SHV beta-lactamase | 分子名称: | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Rodkey, E.A, van den Akker, F. | 登録日 | 2012-05-26 | 公開日 | 2012-09-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase J.Am.Chem.Soc., 134, 2012
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7BDR
| Structure of CTX-M-15 E166Q mutant crystallised in the presence of tazobactam (AAI101) | 分子名称: | Beta-lactamase, CHLORIDE ION, SODIUM ION, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2020-12-22 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (0.91 Å) | 主引用文献 | Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition. Mbio, 13, 2022
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7BDS
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7BJ9
| Structure of Sfh-I with 2-Mercaptomethyl-thiazolidine L-anti-1a | 分子名称: | (2~{S},4~{R})-2-ethoxycarbonyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, GLYCEROL, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2021-01-14 | 公開日 | 2021-08-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.21000588 Å) | 主引用文献 | 2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-beta-Lactamase Classes by Maintaining a Conserved Binding Mode. Acs Infect Dis., 7, 2021
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