8SQ7

X-ray crystal structure of Acinetobacter baumanii beta-lactamase variant OXA-82 K83D in complex with doripenem

Summary for 8SQ7

• Entry DOI: 10.2210/pdb8sq7/pdb
• Descriptor: Beta-lactamase OXA-82, (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, CITRATE ANION, ... (5 entities in total)
• Functional Keywords: acinetobacter beta-lactamase complex carbapenem doripenem, hydrolase, hydrolase-inhibitor, antibiotic complex, hydrolase/inhibitor, antibiotic
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 8
• Total formula weight: 229325.02

Authors

Powers, R.A.,Leonard, D.A.,June, C.M.,Szarecka, A.,Wawrzak, Z. (deposition date: 2023-05-04, release date: 2024-05-22, Last modification date: 2024-05-29)

• Primary citation: Klamer, Z.L.,June, C.M.,Wawrzak, Z.,Taracila, M.A.,Grey, J.A.,Benn, A.M.I.,Russell, C.P.,Bonomo, R.A.,Powers, R.A.,Leonard, D.A.,Szarecka, A.; Structural and Dynamic Features of Acinetobacter baumannii OXA-66 beta-Lactamase Explain Its Stability and Evolution of Novel Variants.; J.Mol.Biol., 436:168603-168603, 2024; PubMed: 38729259; DOI: 10.1016/j.jmb.2024.168603

Experimental method

X-RAY DIFFRACTION (1.78 Å)