7ZO5

L1 metallo-beta-lactamase in complex with a mecillinam degradation product

Summary for 7ZO5

Entry DOI	10.2210/pdb7zo5/pdb
Descriptor	Metallo-beta-lactamase L1, ZINC ION, (2~{R},4~{S})-2-[(1~{R})-2-(azepan-1-yl)-1-formamido-2-oxidanylidene-ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total)
Functional Keywords	antibiotic, ligand, zinc, antimicrobial protein
Biological source	Stenotrophomonas maltophilia
Total number of polymer chains	1
Total formula weight	29561.00
Authors	Hinchliffe, P.,Spencer, J. (deposition date: 2022-04-24, release date: 2023-03-08, Last modification date: 2024-02-07)
Primary citation	Hinchliffe, P.,Calvopina, K.,Rabe, P.,Mojica, M.F.,Schofield, C.J.,Dmitrienko, G.I.,Bonomo, R.A.,Vila, A.J.,Spencer, J. Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products. J.Biol.Chem., 299:104606-104606, 2023 Cited by PubMed: 36924941 DOI: 10.1016/j.jbc.2023.104606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation