5VOX
 
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4J2M
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5ZKQ
 | | Crystal structure of the human platelet-activating factor receptor in complex with ABT-491 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, ... | | 著者 | Cao, C, Zhao, Q, Zhang, X.C, Wu, B. | | 登録日 | 2018-03-25 | | 公開日 | 2018-06-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
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2REU
 | | Crystal Structure of the C-terminal of Sau3AI fragment | | 分子名称: | MAGNESIUM ION, Type II restriction enzyme Sau3AI | | 著者 | Hu, X, Yu, F, Xu, C, He, J. | | 登録日 | 2007-09-27 | | 公開日 | 2008-09-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure and function of C-terminal Sau3AI domain
Biochim.Biophys.Acta, 1794, 2009
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5ZKP
 | | Crystal structure of the human platelet-activating factor receptor in complex with SR 27417 | | 分子名称: | FLAVIN MONONUCLEOTIDE, N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine, Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor | | 著者 | Cao, C, Zhao, Q, Zhang, X.C, Wu, B. | | 登録日 | 2018-03-25 | | 公開日 | 2018-06-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
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7UFG
 | | Cryo-EM structure of PAPP-A in complex with IGFBP5 | | 分子名称: | Insulin-like growth factor-binding protein 5, Pappalysin-1, ZINC ION | | 著者 | Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D. | | 登録日 | 2022-03-22 | | 公開日 | 2022-09-28 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Nat Commun, 13, 2022
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2YB4
 | | Structure of an amidohydrolase from Chromobacterium violaceum (EFI target EFI-500202) with bound SO4, no metal | | 分子名称: | AMIDOHYDROLASE, SULFATE ION | | 著者 | Vetting, M.W, Hillerich, B, Foti, R, Seidel, R.D, Zencheck, W.D, Toro, R, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C. | | 登録日 | 2011-03-01 | | 公開日 | 2011-03-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Prospecting for Unannotated Enzymes: Discovery of a 3',5'-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily.
Biochemistry, 53, 2014
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2YB1
 | | Structure of an amidohydrolase from Chromobacterium violaceum (EFI target EFI-500202) with bound Mn, AMP and phosphate. | | 分子名称: | ADENOSINE MONOPHOSPHATE, AMIDOHYDROLASE, MANGANESE (II) ION, ... | | 著者 | Vetting, M.W, Hillerich, B, Foti, R, Seidel, R.D, Zencheck, W.D, Toro, R, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C. | | 登録日 | 2011-02-25 | | 公開日 | 2011-03-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | | 主引用文献 | Prospecting for Unannotated Enzymes: Discovery of a 3',5'-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily.
Biochemistry, 53, 2014
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8DS8
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3KDU
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8ESM
 | | Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor | | 分子名称: | Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid | | 著者 | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | | 登録日 | 2022-10-14 | | 公開日 | 2023-06-07 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.
Nat Commun, 14, 2023
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8ETM
 | | Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor | | 分子名称: | Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid | | 著者 | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | | 登録日 | 2022-10-17 | | 公開日 | 2023-06-07 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.
Nat Commun, 14, 2023
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3KDT
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7L0X
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7L0Y
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7L0U
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7L0W
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7L0V
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3O8V
 | | Crystal Structure of the Tudor Domains from FXR1 | | 分子名称: | Fragile X mental retardation syndrome-related protein 1 | | 著者 | Lam, R, Guo, Y.H, Adams-Cioaba, M, Bian, C.B, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2010-08-03 | | 公開日 | 2010-08-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2.
Plos One, 5, 2010
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7MDY
 | | LolCDE nucleotide-bound | | 分子名称: | ADP ORTHOVANADATE, Lipo-releasing system transmembrane protein lolC, Lipoprotein transporter subunit LolE, ... | | 著者 | Sharma, S, Liao, M. | | 登録日 | 2021-04-06 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins
Nat Commun, 12, 2021
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7MDX
 | | LolCDE nucleotide-free | | 分子名称: | (2R)-2-(tridecanoyloxy)propyl hexadecanoate, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, ... | | 著者 | Sharma, S, Liao, M. | | 登録日 | 2021-04-06 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins
Nat Commun, 12, 2021
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7MET
 | | A. baumannii MsbA in complex with TBT1 decoupler | | 分子名称: | 2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid, ATP-dependent lipid A-core flippase | | 著者 | Thelot, F, Liao, M. | | 登録日 | 2021-04-07 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
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7MEW
 | | E. coli MsbA in complex with G247 | | 分子名称: | (2E)-3-{1-cyclopropyl-7-[(1S)-1-(3,6-dichloro-2-fluorophenyl)ethoxy]naphthalen-2-yl}prop-2-enoic acid, ATP-dependent lipid A-core flippase | | 著者 | Thelot, F, Liao, M. | | 登録日 | 2021-04-08 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
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3FDR
 | | Crystal structure of TDRD2 | | 分子名称: | Tudor and KH domain-containing protein | | 著者 | Amaya, M.F, Adams, M.A, Guo, Y, Li, Y, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2008-11-26 | | 公開日 | 2009-01-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi
Proc.Natl.Acad.Sci.USA, 106, 2009
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7WVQ
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