7MEW

E. coli MsbA in complex with G247

Summary for 7MEW

Entry DOI	10.2210/pdb7mew/pdb
EMDB information	23805
Descriptor	ATP-dependent lipid A-core flippase, (2E)-3-{1-cyclopropyl-7-[(1S)-1-(3,6-dichloro-2-fluorophenyl)ethoxy]naphthalen-2-yl}prop-2-enoic acid (2 entities in total)
Functional Keywords	membrane protein
Biological source	Escherichia coli (strain B / BL21-DE3)
Total number of polymer chains	2
Total formula weight	135511.51
Authors	Thelot, F.,Liao, M. (deposition date: 2021-04-08, release date: 2021-10-06, Last modification date: 2021-11-10)
Primary citation	Thelot, F.A.,Zhang, W.,Song, K.,Xu, C.,Huang, J.,Liao, M. Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374:580-585, 2021 Cited by PubMed: 34554829 DOI: 10.1126/science.abi9009 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation