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8KAJ
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BU of 8kaj by Molmil
Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 16nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*CP*AP*AP*TP*AP*CP*CP*TP*TP*TP*TP*AP*TP*CP*CP*AP*TP*AP*AP*AP*TP*TP*CP*G)-3'), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.42 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
8KAI
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BU of 8kai by Molmil
Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 17nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (25-MER), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.49 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
8KAM
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BU of 8kam by Molmil
Crystal structure of SpyCas9 in complex with sgRNA and 16nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*CP*AP*AP*TP*AP*CP*CP*TP*CP*TP*TP*CP*AP*AP*TP*TP*AP*GP*AP*AP*CP*AP*CP*G)-3'), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.91 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
7PAK
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BU of 7pak by Molmil
70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
登録日2021-07-30
公開日2022-05-25
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (5.3 Å)
主引用文献Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
8KAL
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BU of 8kal by Molmil
Crystal structure of SpyCas9 in complex with sgRNA and 17nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (25-MER), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
8KAH
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BU of 8kah by Molmil
Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 18nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (26-MER), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.36 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
8KAK
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BU of 8kak by Molmil
Crystal structure of SpyCas9 in complex with sgRNA and 18nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (26-MER), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
8KAG
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BU of 8kag by Molmil
Crystal structure of SpyCas9 in complex with sgRNA and target RNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, RNA (5'-R(*CP*CP*AP*CP*UP*UP*CP*AP*AP*UP*UP*AP*GP*AP*AP*CP*AP*CP*GP*GP*AP*CP*C)-3'), RNA (98-MER)
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.88 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
4A5U
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BU of 4a5u by Molmil
Turnip yellow mosaic virus proteinase and Escherichia coli 30S ribosomal S15
分子名称: 30S RIBOSOMAL PROTEIN S15, RNA REPLICASE POLYPROTEIN
著者Robin, C, Beaurepaire, L, Bressanelli, S.
登録日2011-10-28
公開日2012-11-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Compact Viral Processing Proteinase/Ubiquitin Hydrolase from the Otu Family.
Plos Pathog., 9, 2013
7B5G
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BU of 7b5g by Molmil
Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527)
分子名称: 1,2-ETHANEDIOL, LexA repressor, Nanobody Nb14527, ...
著者Maso, L, Vascon, F, Chinellato, M, Pardon, E, Steyaert, J, Angelini, A, Tondi, D, Cendron, L.
登録日2020-12-03
公開日2022-09-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway.
Structure, 30, 2022
4ARA
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BU of 4ara by Molmil
Mus musculus Acetylcholinesterase in complex with (R)-C5685 at 2.5 A resolution.
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(DIMETHYLAMINO)-N-{[(2R)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2-METHOXY-5-NITROBENZAMIDE, ...
著者Berg, L, Niemiec, M.S, Qian, W, Andersson, C.D, WittungStafshede, P, Ekstrom, F, Linusson, A.
登録日2012-04-23
公開日2012-11-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Similar But Different: Thermodynamic and Structural Characterization of a Pair of Enantiomers Binding to Acetylcholinesterase.
Angew.Chem.Int.Ed.Engl., 51, 2012
8HF6
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BU of 8hf6 by Molmil
Cryo-EM structure of nucleotide-bound ComA E647Q mutant
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Competence factor transporting ATP-binding protein/permease ComA
著者Yu, L, Xin, X, Min, L.
登録日2022-11-09
公開日2023-10-04
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
6GNL
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BU of 6gnl by Molmil
Zr(IV)-substituted Keggin directly binding to the side chain of Hen Egg-White Lysozyme (HEWL)
分子名称: CHLORIDE ION, Lysozyme C, ZIRCONIUM(IV) PHOSPHOTUNGSTATE KEGGIN
著者Vandebroek, L, Van Meervelt, L, Parac-Vogt, T.N.
登録日2018-05-31
公開日2018-10-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Direct observation of the ZrIVinteraction with the carboxamide bond in a noncovalent complex between Hen Egg White Lysozyme and a Zr-substituted Keggin polyoxometalate.
Acta Crystallogr C Struct Chem, 74, 2018
8HF4
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BU of 8hf4 by Molmil
Cryo-EM structure of nucleotide-bound ComA at outward-facing state with EC gate closed conformation
分子名称: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transport/processing ATP-binding protein ComA
著者Yu, L, Xin, X, Min, L.
登録日2022-11-09
公開日2023-10-04
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
4ALU
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BU of 4alu by Molmil
Benzofuropyrimidinone Inhibitors of Pim-1
分子名称: 8-bromo-2-(2-chlorophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one, IMIDAZOLE, SERINE/THREONINE-PROTEIN KINASE PIM-1
著者Stout, T.J, Adams, L.
登録日2012-03-05
公開日2013-01-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
5EGM
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BU of 5egm by Molmil
Development of a novel tricyclic class of potent and selective FIXa inhibitors
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-chloranyl-~{N}-[(7~{S})-2-methyl-7-phenyl-10-(1~{H}-1,2,3,4-tetrazol-5-yl)-8,9-dihydro-6~{H}-pyrido[1,2-a]indol-7-yl]-4-(1,2,4-triazol-4-yl)benzamide, Coagulation factor IX, ...
著者Meng, D, Andre, P, Bateman, T.J, Berger, R, Chen, Y, Desai, K, Dewnani, S, Ellsworth, K, Feng, D, Geissler, W.M, Guo, L, Hruza, A, Jian, T, Li, H, Parker, D.L, Reichert, P, Sherer, E.C, Smith, C.J, Sonatore, L.M, Tschirret-Guth, R, Wu, J, Xu, J, Zhang, T, Campeau, L, Orr, R, Poirier, M, McCabe-Dunn, j, Araki, K, Nishimura, T, Sakurada, I, Hirabayashi, T, Wood, H.B.
登録日2015-10-27
公開日2015-11-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.841 Å)
主引用文献Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
8HF7
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BU of 8hf7 by Molmil
Cryo-EM structure of ComA bound to its mature substrate CSP peptide
分子名称: Competence factor transporting ATP-binding protein/permease ComA, Competence-stimulating peptide type 1
著者Yu, L, Xin, X, Min, L.
登録日2022-11-09
公開日2023-10-11
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
4ODC
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BU of 4odc by Molmil
Crystal structure of Trematomus bernacchii hemoglobin in a partially cyanided state
分子名称: CYANIDE ION, GLYCEROL, Hemoglobin subunit alpha, ...
著者Mazzarella, L, Merlino, A, Vitagliano, L, Vergara, A.
登録日2014-01-10
公開日2014-12-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structural modifications induced by the switch from an endogenous bis-histidyl to an exogenous cyanomet hexa-coordination in a tetrameric haemoglobin
RSC ADV, 4, 2014
2OKA
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BU of 2oka by Molmil
Crystal structure of Q9HYQ7_PSEAE from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium target PaR82
分子名称: Hypothetical protein
著者Benach, J, Neely, H, Seetharaman, J, Chen, X.C, Fang, Y, Cunningham, K, Owens, L, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2007-01-16
公開日2007-01-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Q9HYQ7_PSEAE from Pseudomonas aeruginosa
To be Published
4OHF
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BU of 4ohf by Molmil
Crystal structure of cytosolic nucleotidase II (LPG0095) in complex with GMP from Legionella pneumophila, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET LGR1
分子名称: Cytosolic IMP-GMP specific 5'-nucleotidase, GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, ...
著者Srinivisan, B, Forouhar, F, Shukla, A, Sampangi, C, Kulkarni, S, Abashidze, M, Seetharaman, J, Lew, S, Mao, L, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.M, Tong, L, Balaram, H, Northeast Structural Genomics Consortium (NESG)
登録日2014-01-17
公開日2014-02-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila.
Febs J., 281, 2014
6FHJ
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BU of 6fhj by Molmil
Structural dynamics and catalytic properties of a multi-modular xanthanase, native.
分子名称: CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Moroz, O.V, Jensen, P.F, McDonald, S.P, McGregor, N, Blagova, E, Comamala, G, Segura, D.R, Anderson, L, Vasu, S.M, Rao, V.P, Giger, L, Monrad, R.N, Svendsen, A, Nielsen, J.E, Henrissat, B, Davies, G.J, Brumer, H, Rand, K, Wilson, K.S.
登録日2018-01-14
公開日2018-08-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structural Dynamics and Catalytic Properties of a Multimodular Xanthanase
Acs Catalysis, 2018
8HF5
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BU of 8hf5 by Molmil
Cryo-EM structure of nucleotide-bound ComA at outward-facing state with EC gate open conformation
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transport/processing ATP-binding protein ComA
著者Yu, L, Xin, X, Min, L.
登録日2022-11-09
公開日2023-10-04
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
1SYV
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BU of 1syv by Molmil
HLA-B*4405 complexed to the dominant self ligand EEFGRAYGF
分子名称: Beta-2-microglobulin, MHC class I antigen, major histocompatibility complex, ...
著者Zernich, D, Purcell, A.W, Macdonald, W.A, Kjer-Nielsen, L, Ely, L.K, Laham, N, Crockford, T, Mifsud, N.A, Tait, B.D, Holdsworth, R, Brooks, A.G, Bottomley, S.P, Beddoe, T, Peh, C.A, Rossjohn, J, McCluskey, J.
登録日2004-04-02
公開日2004-10-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion
J.Exp.Med., 200, 2004
7OOC
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BU of 7ooc by Molmil
Mycoplasma pneumoniae 30S subunit of ribosomes in chloramphenicol-treated cells
分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
登録日2021-05-27
公開日2022-05-25
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
7OOD
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BU of 7ood by Molmil
Mycoplasma pneumoniae 50S subunit of ribosomes in chloramphenicol-treated cells
分子名称: 23S ribosomal RNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ...
著者Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
登録日2021-05-27
公開日2022-05-25
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022

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