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8KAI
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BU of 8kai by Molmil
Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 17nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (25-MER), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.49 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
8KAM
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BU of 8kam by Molmil
Crystal structure of SpyCas9 in complex with sgRNA and 16nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*CP*AP*AP*TP*AP*CP*CP*TP*CP*TP*TP*CP*AP*AP*TP*TP*AP*GP*AP*AP*CP*AP*CP*G)-3'), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.91 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
8KAL
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BU of 8kal by Molmil
Crystal structure of SpyCas9 in complex with sgRNA and 17nt target DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (25-MER), DNA (5'-D(*TP*TP*TP*AP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, Y, Chen, J, Liu, L.
登録日2023-08-03
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
6MPM
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BU of 6mpm by Molmil
Racemic M2-TM I42A crystallized from racemic detergent
分子名称: Matrix protein 2, octyl beta-D-glucopyranoside
著者Kreitler, D.F, Yao, Z, Mortenson, D.E, Forest, K.T, Gellman, S.H.
登録日2018-10-07
公開日2019-01-30
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation.
J. Am. Chem. Soc., 141, 2019
6MPL
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BU of 6mpl by Molmil
Racemic M2-TM I39A crystallized from racemic detergent
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Matrix protein 2, octyl beta-D-glucopyranoside
著者Kreitler, D.F, Yao, Z, Mortenson, D.E, Forest, K.T, Gellman, S.H.
登録日2018-10-07
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation.
J. Am. Chem. Soc., 141, 2019
6MPN
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BU of 6mpn by Molmil
Racemic M2-TM I42E crystallized from racemic detergent
分子名称: Matrix protein 2, octyl beta-D-glucopyranoside
著者Kreitler, D.F, Yao, Z, Mortenson, D.E, Forest, K.T, Gellman, S.H.
登録日2018-10-07
公開日2019-01-30
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation.
J. Am. Chem. Soc., 141, 2019
7ECW
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BU of 7ecw by Molmil
The Csy-AcrIF14-dsDNA complex
分子名称: 54-MER DNA, AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, ...
著者Zhang, L.X, Feng, Y.
登録日2021-03-13
公開日2021-11-17
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex.
Nucleic Acids Res., 49, 2021
7ECV
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BU of 7ecv by Molmil
The Csy-AcrIF14 complex
分子名称: AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ...
著者Zhang, L.X, Feng, Y.
登録日2021-03-13
公開日2021-11-17
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex.
Nucleic Acids Res., 49, 2021
7DU0
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BU of 7du0 by Molmil
Structure of an type I-F anti-crispr protein
分子名称: AcrIF14
著者Teng, G, Yue, F.
登録日2021-01-07
公開日2021-11-17
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex.
Nucleic Acids Res., 49, 2021
7C9N
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BU of 7c9n by Molmil
Crystal structure of SETDB1 tudor domain in complexed with Compound 1.
分子名称: 3,5-dimethyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1
著者Guo, Y, Xiong, L, Mao, X, Yang, S.
登録日2020-06-06
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.472 Å)
主引用文献Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.
Angew.Chem.Int.Ed.Engl., 60, 2021
7CJT
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BU of 7cjt by Molmil
Crystal Structure of SETDB1 Tudor domain in complexed with (R,R)-59
分子名称: 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1
著者Guo, Y.P, Liang, X, Mao, X, Wu, C, Luyi, H, Yang, S.
登録日2020-07-13
公開日2021-04-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.474 Å)
主引用文献Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.
Angew.Chem.Int.Ed.Engl., 60, 2021
7CAJ
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BU of 7caj by Molmil
Crystal structure of SETDB1 Tudor domain in complexed with Compound 2.
分子名称: 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-5H-pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1
著者Guo, Y.P, Liang, X, Xin, M, Luyi, H, Chengyong, W, Yang, S.Y.
登録日2020-06-08
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.198 Å)
主引用文献Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.
Angew.Chem.Int.Ed.Engl., 60, 2021
8G83
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BU of 8g83 by Molmil
Structure of NAD+ consuming protein Acinetobacter baumannii TIR domain
分子名称: NAD(+) hydrolase AbTIR
著者Klontz, E.H, Wang, Y, Glendening, G, Carr, J, Tsibouris, T, Buddula, S, Nallar, S, Soares, A, Snyder, G.A.
登録日2023-02-17
公開日2023-10-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献The structure of NAD + consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.
J.Biol.Chem., 299, 2023
5WE2
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BU of 5we2 by Molmil
Structural Basis for Telomere Length Regulation by the Shelterin Bridge
分子名称: DNA-binding protein rap1, Protection of telomeres protein poz1, Protection of telomeres protein tpz1, ...
著者Kim, J.-K, Liu, J, Hu, X, Sankaran, B, Qiao, F.
登録日2017-07-06
公開日2017-12-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Shelterin Bridge Assembly.
Mol. Cell, 68, 2017
5YZ3
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BU of 5yz3 by Molmil
Crystal structure of T2R-TTL-28 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
著者Yu, Y, Chen, Q.
登録日2017-12-12
公開日2018-10-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.545 Å)
主引用文献A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.
Cancer Res., 78, 2018
7XDI
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BU of 7xdi by Molmil
Tail structure of bacteriophage SSV19
分子名称: B210, C131, VP1, ...
著者Liu, H.R, Chen, W.Y.
登録日2022-03-27
公開日2022-08-10
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail.
Proc.Natl.Acad.Sci.USA, 119, 2022
7XSO
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BU of 7xso by Molmil
Structure of the type III-E CRISPR-Cas effector gRAMP
分子名称: RAMP superfamily protein, RNA (35-MER), ZINC ION
著者Feng, Y, Zhang, L.
登録日2022-05-15
公開日2023-03-22
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XSR
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BU of 7xsr by Molmil
Structure of Craspase-target RNA
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ...
著者Feng, Y, Zhang, L.
登録日2022-05-15
公開日2022-11-09
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XSQ
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BU of 7xsq by Molmil
Structure of the Craspase
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ...
著者Feng, Y, Zhang, L.
登録日2022-05-15
公開日2022-11-09
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XT4
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BU of 7xt4 by Molmil
Structure of Craspase-NTR
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ...
著者Feng, Y, Zhang, L.
登録日2022-05-16
公開日2022-11-09
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XPX
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BU of 7xpx by Molmil
Cryo-EM structure of the histone methyltransferase SET8 bound to H4K20Ecx-nucleosome
分子名称: DNA (145-MER), Histone H2A, Histone H2B 1.1, ...
著者Shi, L.X, Zhou, Z.
登録日2022-05-06
公開日2022-06-01
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis of nucleosomal H4K20 methylation by methyltransferase SET8.
Faseb J., 36, 2022
7E4M
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BU of 7e4m by Molmil
Class I Pimarane-Type Diterpene Synthases Stt4548
分子名称: Stt4548
著者Yu, J.H, Xing, B.Y, Ma, M.
登録日2021-02-14
公開日2021-10-06
最終更新日2022-04-20
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
Commun Chem, 4, 2021
7E4O
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BU of 7e4o by Molmil
Class I Pimarane-Type Diterpene Synthases from Actinomycetes
分子名称: Sat1646
著者Yu, J.H, Xing, B.Y, Ma, M.
登録日2021-02-14
公開日2021-10-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
Commun Chem, 4, 2021
7E4N
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BU of 7e4n by Molmil
Crystal structure of Sat1646
分子名称: MAGNESIUM ION, Sat1646
著者Yu, J.H, Xing, B.Y, Ma, M.
登録日2021-02-14
公開日2021-10-06
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
Commun Chem, 4, 2021
7XSP
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BU of 7xsp by Molmil
Structure of gRAMP-target RNA
分子名称: RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ...
著者Feng, Y, Zhang, L.X.
登録日2022-05-15
公開日2022-11-09
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022

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