7CAJ
Crystal structure of SETDB1 Tudor domain in complexed with Compound 2.
Summary for 7CAJ
| Entry DOI | 10.2210/pdb7caj/pdb |
| Descriptor | Histone-lysine N-methyltransferase SETDB1, 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-5H-pyrrolo[3,2-d]pyrimidin-4-one (3 entities in total) |
| Functional Keywords | epigenetic, transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 55901.94 |
| Authors | Guo, Y.P.,Liang, X.,Xin, M.,Luyi, H.,Chengyong, W.,Yang, S.Y. (deposition date: 2020-06-08, release date: 2021-04-07, Last modification date: 2023-11-29) |
| Primary citation | Guo, Y.,Mao, X.,Xiong, L.,Xia, A.,You, J.,Lin, G.,Wu, C.,Huang, L.,Wang, Y.,Yang, S. Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60:8760-8765, 2021 Cited by PubMed: 33511756DOI: 10.1002/anie.202017200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.198 Å) |
Structure validation
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