6Q42
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![BU of 6q42 by Molmil](/molmil-images/mine/6q42) | Crystal Structure of Human Pancreatic Phospholipase A2 | 分子名称: | CHLORIDE ION, Phospholipase A2 | 著者 | Saul, F, Haouz, A, Lambeau, G, Theze, J. | 登録日 | 2018-12-05 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients. J.Clin.Invest., 130, 2020
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8WD4
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![BU of 8wd4 by Molmil](/molmil-images/mine/8wd4) | EGFR(L858R/T790/C797S) in complex with compound 5j | 分子名称: | CHLORIDE ION, Epidermal growth factor receptor, ~{N}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{S})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide | 著者 | Nishikawa, Y. | 登録日 | 2023-09-14 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation. Bioorg.Med.Chem.Lett., 98, 2023
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3J26
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7MTB
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![BU of 7mtb by Molmil](/molmil-images/mine/7mtb) | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 | 分子名称: | Fab6 heavy chain, Fab6 light chain, RETINAL, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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7MT8
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![BU of 7mt8 by Molmil](/molmil-images/mine/7mt8) | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin | 分子名称: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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7MTA
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![BU of 7mta by Molmil](/molmil-images/mine/7mta) | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 | 分子名称: | Fab1 Heavy chain, Fab1 Light chain, RETINAL, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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7MT9
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![BU of 7mt9 by Molmil](/molmil-images/mine/7mt9) | Rhodopsin kinase (GRK1) in complex with rhodopsin | 分子名称: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | 著者 | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2021-05-13 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
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5H3Q
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![BU of 5h3q by Molmil](/molmil-images/mine/5h3q) | Crystal Structure of TrkA kinase with ligand | 分子名称: | 1-[(3S,4R)-4-[3,4-bis(fluoranyl)phenyl]-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenyl-pyrazol-3-yl)urea, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, High affinity nerve growth factor receptor, ... | 著者 | Noritaka, F. | 登録日 | 2016-10-26 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity Bioorg. Med. Chem. Lett., 27, 2017
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8SL4
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8SOA
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![BU of 8soa by Molmil](/molmil-images/mine/8soa) | Phosphoinositide phosphate 3 kinase gamma bound with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | 著者 | Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2023-04-28 | 公開日 | 2024-04-03 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 31, 2024
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8SOE
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8SOB
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![BU of 8sob by Molmil](/molmil-images/mine/8sob) | Phosphoinositide phosphate 3 kinase gamma bound with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | 著者 | Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2023-04-28 | 公開日 | 2024-04-03 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 31, 2024
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8SO9
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![BU of 8so9 by Molmil](/molmil-images/mine/8so9) | Phosphoinositide phosphate 3 kinase gamma | 分子名称: | Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | 著者 | Chen, C.-L, Tesmer, J.J.G. | 登録日 | 2023-04-28 | 公開日 | 2024-04-03 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 31, 2024
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8SL3
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![BU of 8sl3 by Molmil](/molmil-images/mine/8sl3) | Human adenylyl Cyclase 5 in complex with Gbg | 分子名称: | Adenylate cyclase type 5, GERAN-8-YL GERAN, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Yen, Y.C, Tesmer, J.J.G. | 登録日 | 2023-04-20 | 公開日 | 2024-04-03 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia. Nat.Struct.Mol.Biol., 31, 2024
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8SOC
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![BU of 8soc by Molmil](/molmil-images/mine/8soc) | |
8SOD
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5CGY
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6YL6
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![BU of 6yl6 by Molmil](/molmil-images/mine/6yl6) | Cdk2(F80C) | 分子名称: | Cyclin-dependent kinase 2 | 著者 | Craven, G, Morgan, R.M.L, Mann, D.J. | 登録日 | 2020-04-06 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT). Chembiochem, 21, 2020
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5CHN
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8VGR
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8VJS
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8VJR
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6YLK
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![BU of 6ylk by Molmil](/molmil-images/mine/6ylk) | Cdk2(F80C) with Covalent Adduct TK22 at F80C | 分子名称: | Cyclin-dependent kinase 2, methyl 4-ethyl-1-propanoyl-2,3-dihydroquinoxaline-6-carboxylate | 著者 | Craven, G, Morgan, R.M.L, Mann, D.J. | 登録日 | 2020-04-07 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT). Chembiochem, 21, 2020
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6W2U
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6YL1
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![BU of 6yl1 by Molmil](/molmil-images/mine/6yl1) | Cdk2(F80C) with Covalent Adduct TK37 at F80C | 分子名称: | Cyclin-dependent kinase 2, methyl 4-(cyclopropylmethyl)-1-prop-2-enoyl-2,3-dihydroquinoxaline-6-carboxylate | 著者 | Craven, G, Morgan, R.M.L, Mann, D.J. | 登録日 | 2020-04-06 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT). Chembiochem, 21, 2020
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