6VNW
 
 | | Cryo-EM structure of apo-BBSome | | Descriptor: | BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, Bardet-Biedl syndrome 2 protein homolog, ... | | Authors: | Yang, S, Walz, T, Nachury, M, Chou, H. | | Deposit date: | 2020-01-29 | | Release date: | 2020-07-01 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.
Elife, 9, 2020
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6VOA
 | | Cryo-EM structure of the BBSome-ARL6 complex | | Descriptor: | ADP-ribosylation factor-like protein 6, BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, ... | | Authors: | Yang, S, Walz, T, Nachury, M.V. | | Deposit date: | 2020-01-30 | | Release date: | 2020-06-24 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.
Elife, 9, 2020
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5JJY
 | | Crystal structure of SETD2 bound to histone H3.3 K36M peptide | | Descriptor: | Histone H3.3, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Yang, S, Zheng, X, Li, H. | | Deposit date: | 2016-04-25 | | Release date: | 2016-11-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.053 Å) | | Cite: | Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase
Genes Dev., 30, 2016
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3L43
 | | Crystal structure of the dynamin 3 GTPase domain bound with GDP | | Descriptor: | Dynamin-3, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION | | Authors: | Yang, S, Tempel, W, Tong, Y, Nedyalkova, L, Guan, X, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-12-18 | | Release date: | 2010-01-19 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Crystal structure of the dynamin 3 GTPase domain bound with GDP
to be published
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7SC5
 | | Cytoplasmic tail deleted HIV Env trimer in nanodisc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | Authors: | Yang, S, Walz, T. | | Deposit date: | 2021-09-27 | | Release date: | 2022-11-09 | | Last modified: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack.
Nat Commun, 13, 2022
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7SD3
 | | Cytoplasmic tail deleted HIV-1 Env bound with three 4E10 Fabs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4E10 Fab heavy chain, ... | | Authors: | Yang, S, Walz, T. | | Deposit date: | 2021-09-29 | | Release date: | 2022-11-09 | | Last modified: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack.
Nat Commun, 13, 2022
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5XBZ
 | | Crystal structure of GH family 81 beta-1,3-glucanase from Rhizomucr miehei complexed with laminaripentaose | | Descriptor: | Endo-beta-1,3-glucanase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, ... | | Authors: | Yang, S, Qin, Z, Zhou, P, Yan, Q, Jiang, Z. | | Deposit date: | 2017-03-21 | | Release date: | 2018-03-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Catalytic mechanism of glycoside hydrolase family 81 beta-1,3-glucanase
To Be Published
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2KAP
 | | Solution structure of DLC1-SAM | | Descriptor: | Rho GTPase-activating protein 7 | | Authors: | Yang, S, Yang, D. | | Deposit date: | 2008-11-12 | | Release date: | 2009-10-20 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level
Biochemistry, 48, 2009
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6BD4
 | | Crystal structure of human apo-Frizzled4 receptor | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Frizzled-4/Rubredoxin chimeric protein, OLEIC ACID, ... | | Authors: | Yang, S, Wu, Y, Pu, M, Chen, Y, Dong, S, Guo, Y, Han, G.Y, Stevens, R.C, Zhao, S, Xu, F. | | Deposit date: | 2017-10-21 | | Release date: | 2018-08-22 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
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2KET
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8IPJ
 | | Crystal structure of the Legionella effector protein MavL with ADPR-Ub | | Descriptor: | MavL, Ubiquitin, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Ouyang, S, Guan, H. | | Deposit date: | 2023-03-14 | | Release date: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.003 Å) | | Cite: | Crystal structure of the Legionella effector protein MavL with ADPR-Ub
To Be Published
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8IPW
 | | The sturecture of Legionella effector protein MavL with ADPR | | Descriptor: | MavL, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Ouyang, S, Hongxin, G. | | Deposit date: | 2023-03-15 | | Release date: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | The sturecture of Legionella effector protein MavL with ADPR
To Be Published
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3UX9
 | | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus | | Descriptor: | Interferon alpha-1/13, ScFv antibody | | Authors: | Ouyang, S, Zhao, L.X, Liang, W, Shaw, N, Liu, Z.-J, Liang, M.-F. | | Deposit date: | 2011-12-04 | | Release date: | 2012-02-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus
J.Mol.Med., 2012
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4EF5
 | | Crystal structure of STING CTD | | Descriptor: | Transmembrane protein 173 | | Authors: | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | | Deposit date: | 2012-03-29 | | Release date: | 2012-05-16 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
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4EF4
 | | Crystal structure of STING CTD complex with c-di-GMP | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173 | | Authors: | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | | Deposit date: | 2012-03-29 | | Release date: | 2012-05-16 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.147 Å) | | Cite: | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
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7WQY
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7DMS
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4WY5
 | | Structural analysis of two fungal esterases from Rhizomucor miehei explaining their substrate specificity | | Descriptor: | Esterase, SULFATE ION | | Authors: | Qin, Z, Yang, S, Duan, X, Yan, Q, Jiang, Z. | | Deposit date: | 2014-11-15 | | Release date: | 2015-07-01 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structural insights into the substrate specificity of two esterases from the thermophilic Rhizomucor miehei
J.Lipid Res., 56, 2015
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4WY8
 | | Structural analysis of two fungal esterases from Rhizomucor miehei explaining their substrate specificity | | Descriptor: | esterase | | Authors: | Qin, Z, Yang, S, Duan, X, Yan, Q, Jiang, Z. | | Deposit date: | 2014-11-16 | | Release date: | 2015-07-01 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Structural insights into the substrate specificity of two esterases from the thermophilic Rhizomucor miehei
J.Lipid Res., 56, 2015
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5JLE
 | | Crystal structure of SETD2 bound to SAH | | Descriptor: | Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | | Authors: | Li, H, Yang, S, Zheng, X. | | Deposit date: | 2016-04-27 | | Release date: | 2016-11-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase
Genes Dev., 30, 2016
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5JLB
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8H5D
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6J9J
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5XDM
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5XC2
 | | Crystal structure of GH family 81 beta-1,3-glucanase from Rhizomucr miehei complexed with laminarihexaose | | Descriptor: | Endo-beta-1,3-glucanase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, ... | | Authors: | Qin, Z, Yang, S, Peng, Z, Yan, Q, Jiang, Z. | | Deposit date: | 2017-03-22 | | Release date: | 2018-03-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Catalytic mechanism of glycoside hydrolase family 81 beta-1,3-glucanase
To Be Published
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