1QZ7
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![BU of 1qz7 by Molmil](/molmil-images/mine/1qz7) | Beta-catenin binding domain of Axin in complex with beta-catenin | Descriptor: | Axin, Beta-catenin | Authors: | Xing, Y, Clements, W.K, Kimelman, D, Xu, W. | Deposit date: | 2003-09-15 | Release date: | 2003-11-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the {beta}-catenin destruction complex GENES DEV., 17, 2003
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1ACI
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![BU of 1aci by Molmil](/molmil-images/mine/1aci) | |
2IE4
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![BU of 2ie4 by Molmil](/molmil-images/mine/2ie4) | Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid | Descriptor: | MANGANESE (II) ION, OKADAIC ACID, Protein Phosphatase 2, ... | Authors: | Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y. | Deposit date: | 2006-09-17 | Release date: | 2006-11-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins Cell(Cambridge,Mass.), 127, 2006
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2IE3
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![BU of 2ie3 by Molmil](/molmil-images/mine/2ie3) | Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins | Descriptor: | MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ... | Authors: | Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y. | Deposit date: | 2006-09-17 | Release date: | 2006-11-07 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins Cell(Cambridge,Mass.), 127, 2006
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3C5W
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![BU of 3c5w by Molmil](/molmil-images/mine/3c5w) | Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme | Descriptor: | PP2A A subunit, PP2A C subunit, PP2A-specific methylesterase PME-1 | Authors: | Xing, Y, Li, Z, Chen, Y, Stock, J, Jeffrey, P.D, Shi, Y. | Deposit date: | 2008-02-01 | Release date: | 2008-04-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell(Cambridge,Mass.), 133, 2008
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3C5V
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![BU of 3c5v by Molmil](/molmil-images/mine/3c5v) | PP2A-specific methylesterase apo form (PME) | Descriptor: | Protein phosphatase methylesterase 1 | Authors: | Xing, Y, Li, Z, Chen, Y, Stock, J, Jeffrey, P.D, Shi, Y. | Deposit date: | 2008-02-01 | Release date: | 2008-04-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell(Cambridge,Mass.), 133, 2008
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4XHJ
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![BU of 4xhj by Molmil](/molmil-images/mine/4xhj) | gHgL of Varicella-zoster virus in complex with human neutralizing antibodies. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, ... | Authors: | Xing, Y. | Deposit date: | 2015-01-05 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.156 Å) | Cite: | A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL. Proc.Natl.Acad.Sci.USA, 112, 2015
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4XI5
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![BU of 4xi5 by Molmil](/molmil-images/mine/4xi5) | gHgL of varicella-zoster virus in complex with human neutralizing antibodies | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ... | Authors: | Xing, Y. | Deposit date: | 2015-01-06 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL. Proc.Natl.Acad.Sci.USA, 112, 2015
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1XTE
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![BU of 1xte by Molmil](/molmil-images/mine/1xte) | crystal structure of CISK-PX domain | Descriptor: | Serine/threonine-protein kinase Sgk3 | Authors: | Xing, Y, Liu, D, Zhang, R, Joachimiak, A, Songyang, Z, Xu, W. | Deposit date: | 2004-10-21 | Release date: | 2004-11-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX) J.Biol.Chem., 279, 2004
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1XTN
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![BU of 1xtn by Molmil](/molmil-images/mine/1xtn) | crystal structure of CISK-PX domain with sulfates | Descriptor: | SULFATE ION, Serine/threonine-protein kinase Sgk3 | Authors: | Xing, Y, Liu, D, Zhang, R, Joachimiak, A, Songyang, Z, Xu, W. | Deposit date: | 2004-10-22 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX) J.Biol.Chem., 279, 2004
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1TH1
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![BU of 1th1 by Molmil](/molmil-images/mine/1th1) | Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment | Descriptor: | Adenomatous polyposis coli protein, Beta-catenin | Authors: | Xing, Y, Clements, W.K, Le Trong, I, Hinds, T.R, Stenkamp, R, Kimelman, D, Xu, W. | Deposit date: | 2004-05-31 | Release date: | 2004-09-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of a beta-Catenin/APC Complex Reveals a Critical Role for APC Phosphorylation in APC Function. Mol.Cell, 15, 2004
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2Z6H
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![BU of 2z6h by Molmil](/molmil-images/mine/2z6h) | Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain | Descriptor: | Catenin beta-1 | Authors: | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | Deposit date: | 2007-08-01 | Release date: | 2008-02-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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2Z6G
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![BU of 2z6g by Molmil](/molmil-images/mine/2z6g) | Crystal Structure of a Full-Length Zebrafish Beta-Catenin | Descriptor: | B-catenin | Authors: | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | Deposit date: | 2007-08-01 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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2NYL
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![BU of 2nyl by Molmil](/molmil-images/mine/2nyl) | Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated | Descriptor: | MANGANESE (II) ION, Protein phosphatase 2, regulatory subunit A (PR 65), ... | Authors: | Xing, Y, Xu, Y, Chen, Y, Chao, Y, Lin, Z, Shi, Y. | Deposit date: | 2006-11-20 | Release date: | 2006-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006
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3P71
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![BU of 3p71 by Molmil](/molmil-images/mine/3p71) | Crystal structure of the complex of LCMT-1 and PP2A | Descriptor: | 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, DI(HYDROXYETHYL)ETHER, Leucine carboxyl methyltransferase 1, ... | Authors: | Xing, Y, Stanevich, V, Satyshur, K.A, Jiang, L. | Deposit date: | 2010-10-11 | Release date: | 2011-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1. Mol.Cell, 41, 2011
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3IEI
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![BU of 3iei by Molmil](/molmil-images/mine/3iei) | |
6VLK
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![BU of 6vlk by Molmil](/molmil-images/mine/6vlk) | A varicella-zoster virus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B, ... | Authors: | Xing, Y. | Deposit date: | 2020-01-24 | Release date: | 2020-07-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4529 Å) | Cite: | A glycoprotein B-neutralizing antibody structure at 2.8 angstrom uncovers a critical domain for herpesvirus fusion initiation. Nat Commun, 11, 2020
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4I5K
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![BU of 4i5k by Molmil](/molmil-images/mine/4i5k) | |
4I5J
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![BU of 4i5j by Molmil](/molmil-images/mine/4i5j) | PP2A PR70 Holoenzyme | Descriptor: | CALCIUM ION, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha | Authors: | Xing, Y, Jeffery, P.D, Shi, Y. | Deposit date: | 2012-11-28 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res., 23, 2013
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5W0W
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![BU of 5w0w by Molmil](/molmil-images/mine/5w0w) | Crystal structure of Protein Phosphatase 2A bound to TIPRL | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... | Authors: | Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y. | Deposit date: | 2017-06-01 | Release date: | 2018-01-17 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Methylation-regulated decommissioning of multimeric PP2A complexes. Nat Commun, 8, 2017
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8RIJ
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![BU of 8rij by Molmil](/molmil-images/mine/8rij) | Discovery of the first orally bioavailable ADAMTS7 inhibitor BAY-9835 | Descriptor: | CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Schafer, M, Meibom, D, Wasnaire, P, Beyer, K, Broehl, A, Cancho-Grande, Y, Elowe, N, Henninger, K, Johannes, S, Jungmann, N, Krainz, T, Lindner, N, Maassen, S, MacDonald, B, Menshykau, D, Mittendorf, J, Sanchez, G, Stefan, E, Torge, A, Xing, Y, Zubov, D. | Deposit date: | 2023-12-18 | Release date: | 2024-02-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor. J.Med.Chem., 67, 2024
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7SOY
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![BU of 7soy by Molmil](/molmil-images/mine/7soy) | The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex | Descriptor: | Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y. | Deposit date: | 2021-11-01 | Release date: | 2022-08-31 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition. Elife, 11, 2022
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1EB6
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![BU of 1eb6 by Molmil](/molmil-images/mine/1eb6) | Deuterolysin from Aspergillus oryzae | Descriptor: | 1,2-ETHANEDIOL, NEUTRAL PROTEASE II, ZINC ION | Authors: | McAuley, K.E, Jia-Xing, Y, Dodson, E.J, Lehmbeck, J, Ostergaard, P.R, Wilson, K.S. | Deposit date: | 2001-07-19 | Release date: | 2001-11-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | A Quick Solution: Ab Initio Structure Determination of a 19 kDa Metalloproteinase Using Acorn Acta Crystallogr.,Sect.D, 57, 2001
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2NYM
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![BU of 2nym by Molmil](/molmil-images/mine/2nym) | Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit | Descriptor: | MANGANESE (II) ION, Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | Authors: | Chen, Y, Xing, Y, Xu, Y, Chao, Y, Lin, Z, Jeffrey, P.D, Shi, Y. | Deposit date: | 2006-11-21 | Release date: | 2006-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006
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2NPP
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![BU of 2npp by Molmil](/molmil-images/mine/2npp) | Structure of the Protein Phosphatase 2A Holoenzyme | Descriptor: | MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ... | Authors: | Xu, Y, Chen, Y, Xing, Y, Chao, Y, Shi, Y. | Deposit date: | 2006-10-28 | Release date: | 2006-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of the protein phosphatase 2A holoenzyme Cell(Cambridge,Mass.), 127, 2006
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