4XI5

gHgL of varicella-zoster virus in complex with human neutralizing antibodies

Summary for 4XI5

Entry DOI	10.2210/pdb4xi5/pdb
Related	4XHJ
Descriptor	Envelope glycoprotein H, Envelope glycoprotein L, Fab-94 light chain, ... (6 entities in total)
Functional Keywords	complex, neutralization epitope, viral protein-immune system complex, viral protein/immune system
Biological source	Human herpesvirus 3 strain Oka vaccine (HHV-3) More
Cellular location	Virion membrane ; Single-pass type I membrane protein : Q775J3 Virion membrane ; Peripheral membrane protein ; Extracellular side : Q9J3N1
Total number of polymer chains	4
Total formula weight	162744.49
Authors	Xing, Y. (deposition date: 2015-01-06, release date: 2015-05-13, Last modification date: 2023-09-27)
Primary citation	Xing, Y.,Oliver, S.L.,Nguyen, T.,Ciferri, C.,Nandi, A.,Hickman, J.,Giovani, C.,Yang, E.,Palladino, G.,Grose, C.,Uematsu, Y.,Lilja, A.E.,Arvin, A.M.,Carfi, A. A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL. Proc.Natl.Acad.Sci.USA, 112:6056-6061, 2015 Cited by PubMed: 25918416 DOI: 10.1073/pnas.1501176112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.9 Å)

Structure validation