8RIJ
Discovery of the first orally bioavailable ADAMTS7 inhibitor BAY-9835
This is a non-PDB format compatible entry.
Summary for 8RIJ
Entry DOI | 10.2210/pdb8rij/pdb |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | matrix metalloproteinase, mmp12, metallo elastase, extracellular matrix, hydrolase, metal-binding, metalloprotease |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18235.43 |
Authors | Schafer, M.,Meibom, D.,Wasnaire, P.,Beyer, K.,Broehl, A.,Cancho-Grande, Y.,Elowe, N.,Henninger, K.,Johannes, S.,Jungmann, N.,Krainz, T.,Lindner, N.,Maassen, S.,MacDonald, B.,Menshykau, D.,Mittendorf, J.,Sanchez, G.,Stefan, E.,Torge, A.,Xing, Y.,Zubov, D. (deposition date: 2023-12-18, release date: 2024-02-21, Last modification date: 2024-03-06) |
Primary citation | Meibom, D.,Wasnaire, P.,Beyer, K.,Broehl, A.,Cancho-Grande, Y.,Elowe, N.,Henninger, K.,Johannes, S.,Jungmann, N.,Krainz, T.,Lindner, N.,Maassen, S.,MacDonald, B.,Menshykau, D.,Mittendorf, J.,Sanchez, G.,Schaefer, M.,Stefan, E.,Torge, A.,Xing, Y.,Zubov, D. BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor. J.Med.Chem., 67:2907-2940, 2024 Cited by PubMed: 38348661DOI: 10.1021/acs.jmedchem.3c02036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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