2HDB
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1JM6
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![BU of 1jm6 by Molmil](/molmil-images/mine/1jm6) | Pyruvate dehydrogenase kinase, isozyme 2, containing ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pyruvate dehydrogenase kinase, ... | Authors: | Steussy, C.N, Popov, K.M, Bowker-Kinley, M.M, Sloan, R.B, Harris, R.A, Hamilton, J.A. | Deposit date: | 2001-07-17 | Release date: | 2001-10-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase. J.Biol.Chem., 276, 2001
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1X9E
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![BU of 1x9e by Molmil](/molmil-images/mine/1x9e) | Crystal structure of HMG-CoA synthase from Enterococcus faecalis | Descriptor: | HMG-CoA synthase, SULFATE ION | Authors: | Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2004-08-20 | Release date: | 2005-11-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA Biochemistry, 44, 2005
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1YSL
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![BU of 1ysl by Molmil](/molmil-images/mine/1ysl) | Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand. | Descriptor: | ACETOACETIC ACID, COENZYME A, GLYCEROL, ... | Authors: | Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2005-02-08 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA. Biochemistry, 44, 2005
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4I56
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![BU of 4i56 by Molmil](/molmil-images/mine/4i56) | HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa | Descriptor: | (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... | Authors: | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Crichelow, C.J, Rodwell, V.W, Wrensford, L.V, Min, J, Burgner II, J.W. | Deposit date: | 2012-11-28 | Release date: | 2013-07-17 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
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4I6Y
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![BU of 4i6y by Molmil](/molmil-images/mine/4i6y) | 3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate | Descriptor: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... | Authors: | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | Deposit date: | 2012-11-30 | Release date: | 2013-07-17 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
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4I6A
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![BU of 4i6a by Molmil](/molmil-images/mine/4i6a) | 3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with HMG-CoA | Descriptor: | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION | Authors: | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | Deposit date: | 2012-11-29 | Release date: | 2013-07-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
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4I6W
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![BU of 4i6w by Molmil](/molmil-images/mine/4i6w) | 3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate | Descriptor: | (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ... | Authors: | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | Deposit date: | 2012-11-30 | Release date: | 2013-07-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
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4I64
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![BU of 4i64 by Molmil](/molmil-images/mine/4i64) | 3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution native structure | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION | Authors: | Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J. | Deposit date: | 2012-11-29 | Release date: | 2013-07-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
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4I4B
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![BU of 4i4b by Molmil](/molmil-images/mine/4i4b) | HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA | Descriptor: | (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, ... | Authors: | Stauffacher, C.V, Steussy, C.N, Critchelow, C.J, Schmidt, T, Min, J, Wrensford, L.V, Burgner, J.W, Rodwell, V.W. | Deposit date: | 2012-11-27 | Release date: | 2013-07-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Biochemistry, 52, 2013
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8GDN
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![BU of 8gdn by Molmil](/molmil-images/mine/8gdn) | Structure of PmHMGR bound to mevalonate, CoA and NAD. | Descriptor: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... | Authors: | Purohit, V, Steussy, C.N, Stauffacher, C.V. | Deposit date: | 2023-03-06 | Release date: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J., 123, 2024
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7M1Z
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7M3H
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7M66
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8SZ6
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![BU of 8sz6 by Molmil](/molmil-images/mine/8sz6) | PmHMGR bound to mevaldehyde and CoA | Descriptor: | (3R)-3,5,5-trihydroxy-3-methylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Mevaldyl-Coenzyme A, ... | Authors: | Purohit, V, Stauffacher, C.V, Steussy, C.N. | Deposit date: | 2023-05-27 | Release date: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J., 123, 2024
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8VLQ
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![BU of 8vlq by Molmil](/molmil-images/mine/8vlq) | Structure of PmHMGR bound to mevalonate, CoA and NAD 5 minutes after reaction initiation at pH 9 | Descriptor: | (R)-MEVALONATE, (R)-mevaldehyde, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | Authors: | Purohit, V, Steussy, C.N, Stauffacher, C.V. | Deposit date: | 2024-01-12 | Release date: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J., 123, 2024
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2PNR
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![BU of 2pnr by Molmil](/molmil-images/mine/2pnr) | Crystal Structure of the asymmetric Pdk3-l2 Complex | Descriptor: | DIHYDROLIPOIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 | Authors: | Vassylyev, D.G, Steussy, C.N, Devedjiev, Y. | Deposit date: | 2007-04-25 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of an Asymmetric complex of Pyruvate Dehydrogenase
Kinase 3 with Lipoyl domain 2 and its Biological Implications J.Mol.Biol., 370, 2007
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5JNP
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![BU of 5jnp by Molmil](/molmil-images/mine/5jnp) | Crystal structure of a rice (Oryza Sativa) cellulose synthase plant conserved region (P-CR) | Descriptor: | CITRATE ANION, GLYCEROL, PHOSPHATE ION, ... | Authors: | Rushton, P.S, Olek, A.T, Makowski, L, Badger, J, Steussy, C.N, Carpita, N.C, Stauffacher, C.V. | Deposit date: | 2016-04-30 | Release date: | 2016-12-28 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.404 Å) | Cite: | Rice Cellulose SynthaseA8 Plant-Conserved Region Is a Coiled-Coil at the Catalytic Core Entrance. Plant Physiol., 173, 2017
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1R7I
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![BU of 1r7i by Molmil](/molmil-images/mine/1r7i) | HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution. | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION | Authors: | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2003-10-21 | Release date: | 2003-11-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase. To be Published
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1R31
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![BU of 1r31 by Molmil](/molmil-images/mine/1r31) | HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA | Descriptor: | (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ... | Authors: | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2003-09-30 | Release date: | 2003-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase. To be Published
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5V2L
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5V2M
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6E2S
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![BU of 6e2s by Molmil](/molmil-images/mine/6e2s) | apo form of MDDEF with buffer exchange | Descriptor: | Mevalonate diphosphate decarboxylase, SULFATE ION | Authors: | Stauffacher, C.V, Chen, C.-L. | Deposit date: | 2018-07-12 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.791 Å) | Cite: | Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase. Nat Commun, 11, 2020
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6E2T
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![BU of 6e2t by Molmil](/molmil-images/mine/6e2t) | MDDEF in complex with MVAPP | Descriptor: | (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, Mevalonate diphosphate decarboxylase | Authors: | Stauffacher, C.V, Chen, C.-L. | Deposit date: | 2018-07-12 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.692 Å) | Cite: | Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase. Nat Commun, 11, 2020
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6E2U
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![BU of 6e2u by Molmil](/molmil-images/mine/6e2u) | MDDEF in complex with MVAPP, AMPPCP and Magnesium | Descriptor: | (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, MAGNESIUM ION, Mevalonate diphosphate decarboxylase, ... | Authors: | Stauffacher, C.V, Chen, C.-L. | Deposit date: | 2018-07-12 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase. Nat Commun, 11, 2020
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