1FS2
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![BU of 1fs2 by Molmil](/molmil-images/mine/1fs2) | INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX | Descriptor: | SKP1, SKP2 | Authors: | Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R.E, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P. | Deposit date: | 2000-09-08 | Release date: | 2000-11-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature, 408, 2000
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1FS1
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![BU of 1fs1 by Molmil](/molmil-images/mine/1fs1) | INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX | Descriptor: | CYCLIN A/CDK2-ASSOCIATED P19, CYCLIN A/CDK2-ASSOCIATED P45 | Authors: | Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R.E, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P. | Deposit date: | 2000-09-08 | Release date: | 2000-11-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature, 408, 2000
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1FQV
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![BU of 1fqv by Molmil](/molmil-images/mine/1fqv) | Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex | Descriptor: | SKP1, SKP2 | Authors: | Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P. | Deposit date: | 2000-09-06 | Release date: | 2000-11-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature, 408, 2000
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8QYM
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![BU of 8qym by Molmil](/molmil-images/mine/8qym) | Human 20S proteasome assembly intermediate structure 3 | Descriptor: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | Authors: | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 2024
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8QYS
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![BU of 8qys by Molmil](/molmil-images/mine/8qys) | Human preholo proteasome 20S core particle | Descriptor: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | Authors: | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 2024
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8QYO
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![BU of 8qyo by Molmil](/molmil-images/mine/8qyo) | Human proteasome 20S core particle | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | Authors: | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 2024
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8QYN
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![BU of 8qyn by Molmil](/molmil-images/mine/8qyn) | Human 20S proteasome assembly intermediate structure 5 | Descriptor: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | Authors: | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 2024
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8QZ9
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![BU of 8qz9 by Molmil](/molmil-images/mine/8qz9) | Human 20S proteasome assembly intermediate structure 4 | Descriptor: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | Authors: | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 2024
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8QYL
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![BU of 8qyl by Molmil](/molmil-images/mine/8qyl) | Human 20S proteasome assembly intermediate structure 2 | Descriptor: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ... | Authors: | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 2024
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8QYJ
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![BU of 8qyj by Molmil](/molmil-images/mine/8qyj) | Human 20S proteasome assembly structure 1 | Descriptor: | Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome assembly chaperone 3, ... | Authors: | Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-21 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nat.Struct.Mol.Biol., 2024
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3IVQ
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![BU of 3ivq by Molmil](/molmil-images/mine/3ivq) | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-CiSBC2 | Descriptor: | CiSBC2, Speckle-type POZ protein | Authors: | Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S. | Deposit date: | 2009-09-01 | Release date: | 2009-10-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases. Mol.Cell, 36, 2009
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3IVV
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![BU of 3ivv by Molmil](/molmil-images/mine/3ivv) | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-PucSBC1_pep1 | Descriptor: | PucSBC1, Speckle-type POZ protein | Authors: | Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S. | Deposit date: | 2009-09-01 | Release date: | 2009-10-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases. Mol.Cell, 36, 2009
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3IVB
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![BU of 3ivb by Molmil](/molmil-images/mine/3ivb) | Structures of SPOP-Substrate Complexes: Insights into Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-MacroH2ASBCpep1 | Descriptor: | CHLORIDE ION, Core histone macro-H2A.1, Speckle-type POZ protein, ... | Authors: | Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S. | Deposit date: | 2009-08-31 | Release date: | 2009-10-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure 9 To be Published
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7OD1
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![BU of 7od1 by Molmil](/molmil-images/mine/7od1) | |
5D7G
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![BU of 5d7g by Molmil](/molmil-images/mine/5d7g) | |
7QQY
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![BU of 7qqy by Molmil](/molmil-images/mine/7qqy) | yeast Gid10 bound to Art2 Pro/N-degron | Descriptor: | CHLORIDE ION, ECM21, Uncharacterized protein YGR066C | Authors: | Chrustowicz, J, Sherpa, D, Schulman, B.A. | Deposit date: | 2022-01-10 | Release date: | 2022-03-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. Embo Rep., 23, 2022
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7WUG
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![BU of 7wug by Molmil](/molmil-images/mine/7wug) | GID subcomplex: Gid12 bound Substrate Receptor Scaffolding module | Descriptor: | Glucose-induced degradation protein 8, HLJ1_G0042170.mRNA.1.CDS.1, Vacuolar import and degradation protein 24, ... | Authors: | Qiao, S, Cheng, J.D, Schulman, B.A. | Deposit date: | 2022-02-08 | Release date: | 2022-06-08 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nat Commun, 13, 2022
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5V86
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![BU of 5v86 by Molmil](/molmil-images/mine/5v86) | Structure of DCN1 bound to NAcM-OPT | Descriptor: | Lysozyme,DCN1-like protein 1, N-benzyl-N-(1-butylpiperidin-4-yl)-N'-(3,4-dichlorophenyl)urea | Authors: | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | Deposit date: | 2017-03-21 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.374 Å) | Cite: | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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5V88
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![BU of 5v88 by Molmil](/molmil-images/mine/5v88) | Structure of DCN1 bound to NAcM-COV | Descriptor: | Lysozyme,DCN1-like protein 1, N-{2-[({1-[(2R)-pentan-2-yl]piperidin-4-yl}{[3-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]phenyl}propanamide | Authors: | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | Deposit date: | 2017-03-21 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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5KHR
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![BU of 5khr by Molmil](/molmil-images/mine/5khr) | Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C) | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-15 | Release date: | 2016-08-24 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63, 2016
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7Q51
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![BU of 7q51 by Molmil](/molmil-images/mine/7q51) | yeast Gid10 bound to a Phe/N-peptide | Descriptor: | CHLORIDE ION, FWLPANLW peptide, Uncharacterized protein YGR066C | Authors: | Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2021-11-02 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. J.Mol.Biol., 434, 2022
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7Q4Y
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![BU of 7q4y by Molmil](/molmil-images/mine/7q4y) | |
7Q50
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![BU of 7q50 by Molmil](/molmil-images/mine/7q50) | human Gid4 bound to a Phe/N-peptide | Descriptor: | FDVSWFMG peptide, Glucose-induced degradation protein 4 homolog | Authors: | Chrustowicz, J, Sherpa, D, Loke, M.S, Prabu, J.R, Schulman, B.A. | Deposit date: | 2021-11-02 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. J.Mol.Biol., 434, 2022
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8OIF
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![BU of 8oif by Molmil](/molmil-images/mine/8oif) | Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6 | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | Authors: | Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N. | Deposit date: | 2023-03-22 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Insights into the ISG15 transfer cascade by the UBE1L activating enzyme. Nat Commun, 14, 2023
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8Q7R
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![BU of 8q7r by Molmil](/molmil-images/mine/8q7r) | Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide | Descriptor: | 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | Deposit date: | 2023-08-16 | Release date: | 2024-02-21 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
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