5IPX
| Structure of ORF49 from KSHV | Descriptor: | ORF49 protein, SULFATE ION | Authors: | Hew, K, Nordlund, P. | Deposit date: | 2016-03-10 | Release date: | 2016-11-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus. J. Virol., 91, 2017
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4XSE
| Complex structure of thymidylate synthase from varicella zoster virus | Descriptor: | PHOSPHATE ION, Thymidylate synthase | Authors: | Hew, K. | Deposit date: | 2015-01-22 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10, 2015
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4XSD
| Complex structure of thymidylate synthase from varicella zoster virus with a dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | Authors: | Hew, K. | Deposit date: | 2015-01-22 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10, 2015
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4XSC
| Complex structure of thymidylate synthase from varicella zoster virus with a phosphorylated BVDU | Descriptor: | (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, Thymidylate synthase | Authors: | Hew, K. | Deposit date: | 2015-01-22 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.901 Å) | Cite: | Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10, 2015
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4XAL
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4HLY
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4HLX
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2JKG
| Plasmodium falciparum profilin | Descriptor: | MAGNESIUM ION, OCTAPROLINE PEPTIDE, PROFILIN | Authors: | Kursula, I, Kursula, P, Ganter, M, Panjikar, S, Matuschewski, K, Schueler, H. | Deposit date: | 2008-08-28 | Release date: | 2008-09-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural Basis for Parasite-Specific Functions of the Divergent Profilin of Plasmodium Falciparum. Structure, 16, 2008
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2JKF
| Plasmodium falciparum profilin | Descriptor: | PROFILIN | Authors: | Kursula, I, Kursula, P, Ganter, M, Panjikar, S, Matuschewski, K, Schueler, H. | Deposit date: | 2008-08-28 | Release date: | 2008-09-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural Basis for Parasite-Specific Functions of the Divergent Profilin of Plasmodium Falciparum Structure, 16, 2008
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2CGO
| FACTOR INHIBITING HIF-1 ALPHA with fumarate | Descriptor: | FE (III) ION, FUMARIC ACID, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, ... | Authors: | McDonough, M.A, Clifton, I.J, Schofield, C.J. | Deposit date: | 2006-03-09 | Release date: | 2006-12-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem., 282, 2007
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2CGN
| FACTOR INHIBITING HIF-1 ALPHA with succinate | Descriptor: | FE (III) ION, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, SUCCINIC ACID, ... | Authors: | McDonough, M.A, Clifton, I.J, Schofield, C.J. | Deposit date: | 2006-03-09 | Release date: | 2006-12-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem., 282, 2007
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7XTP
| eIF4E in Complex with a Disulphide-Free Autonomous VH Domain | Descriptor: | Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | Authors: | Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C. | Deposit date: | 2022-05-17 | Release date: | 2022-07-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.828 Å) | Cite: | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex. Nat Commun, 13, 2022
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7D8B
| Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways | Descriptor: | Eukaryotic translation initiation factor 4E, VH-S4 | Authors: | Frosi, Y, Lin, Y.C, Jiang, S, Brown, C.J. | Deposit date: | 2020-10-07 | Release date: | 2021-08-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex. Nat Commun, 13, 2022
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7D6Y
| eIF4E in Complex with a Disulphide-Free Autonomous VH Domain | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Eukaryotic translation initiation factor 4E, VH Domain (1C5), ... | Authors: | Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C. | Deposit date: | 2020-10-02 | Release date: | 2021-10-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.668 Å) | Cite: | Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways To Be Published
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4K4B
| X-ray crystal structure of E. coli YdiI complexed with undeca-2-one-CoA | Descriptor: | CHLORIDE ION, Esterase YdiI, undeca-2-one coenzyme A | Authors: | Ru, W, Farelli, J.D, Dunaway-Mariano, D, Allen, K.N. | Deposit date: | 2013-04-12 | Release date: | 2014-07-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB. Biochemistry, 53, 2014
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4K4C
| X-ray crystal structure of E. coli YbdB complexed with phenacyl-CoA | Descriptor: | Proofreading thioesterase EntH, phenacyl coenzyme A | Authors: | Ru, W, Farelli, J.D, Dunaway-Mariano, D, Allen, K.N. | Deposit date: | 2013-04-12 | Release date: | 2014-07-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB. Biochemistry, 53, 2014
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4K49
| X-ray crystal structure of E. coli YdiI complexed with 2,4-dihydroxyphenacyl CoA | Descriptor: | 2,4-dihydroxyphenacyl coenzyme A, Esterase YdiI | Authors: | Ru, W, Farelli, J.D, Dunaway-Mariano, D, Allen, K.N. | Deposit date: | 2013-04-12 | Release date: | 2014-07-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB. Biochemistry, 53, 2014
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4HUP
| Structure of ricin A chain bound with N-(N-(pterin-7-yl)carbonylglycyl)-L-phenylalanyl)-L-phenylalanine | Descriptor: | (2S)-2-[[(2S)-2-[2-[(2-azanyl-4-oxidanylidene-1H-pteridin-7-yl)carbonylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-3-phenyl-propanoic acid, MALONIC ACID, Ricin, ... | Authors: | Jasheway, K.R, Monzingo, A.F, Saito, R, Pruet, J.M, Manzano, L.A, Wiget, P.A, Anslyn, E.V, Robertus, J.D. | Deposit date: | 2012-11-02 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Peptide-conjugated pterins as inhibitors of ricin toxin A. J.Med.Chem., 56, 2013
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4HV7
| Structure of ricin A chain bound with N-(N-(pterin-7-yl)carbonylglycyl)glycine | Descriptor: | 2-[2-[(2-azanyl-4-oxidanylidene-1H-pteridin-7-yl)carbonylamino]ethanoylamino]ethanoic acid, MALONIC ACID, Ricin, ... | Authors: | Jasheway, K.R, Monzingo, A.F, Saito, R, Pruet, J.M, Manzano, L.A, Wiget, P.A, Anslyn, E.V, Robertus, J.D. | Deposit date: | 2012-11-05 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.869 Å) | Cite: | Peptide-conjugated pterins as inhibitors of ricin toxin A. J.Med.Chem., 56, 2013
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4HUO
| Structure of Ricin A chain bound with N-(N-(pterin-7-yl)carbonylglycyl)-L-phenylalanine | Descriptor: | N-[(2-amino-4-oxo-1,4-dihydropteridin-7-yl)carbonyl]glycyl-L-phenylalanine, Ricin | Authors: | Jasheway, K.R, Monzingo, A.F, Saito, R, Pruet, J.M, Manzano, L.A, Wiget, P.A, Anslyn, E.V, Robertus, J.D. | Deposit date: | 2012-11-02 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Peptide-conjugated pterins as inhibitors of ricin toxin A. J.Med.Chem., 56, 2013
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4HV3
| Structure of Ricin A chain bound with N-(N-(pterin-7-yl)carbonyl-L-serinyl)-L-tryptophan | Descriptor: | (2S)-2-[[(2S)-2-[(2-azanyl-4-oxidanylidene-1H-pteridin-7-yl)carbonylamino]-3-oxidanyl-propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid, MALONIC ACID, Ricin, ... | Authors: | Robertus, J.D, Manzano, L.A, Jasheway, K.R, Monzingo, A.F, Saito, R, Pruet, J.M, Wiget, P.A, Anslyn, E.V. | Deposit date: | 2012-11-05 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Peptide-conjugated pterins as inhibitors of ricin toxin A. J.Med.Chem., 56, 2013
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7P6N
| ROCK2 IN COMPLEX WITH COMPOUND 12 | Descriptor: | Rho-associated protein kinase 2, ~{N}-[(1~{R})-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-yl-piperidine-1-carboxamide | Authors: | Maillard, M.C. | Deposit date: | 2021-07-16 | Release date: | 2022-07-27 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease. J.Med.Chem., 65, 2022
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4K4A
| X-ray crystal structure of E. coli YdiI complexed with phenacyl-CoA | Descriptor: | Esterase YdiI, phenacyl coenzyme A | Authors: | Ru, W, Farelli, J.D, Dunaway-Mariano, D, Allen, K.N. | Deposit date: | 2013-04-12 | Release date: | 2014-07-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB. Biochemistry, 53, 2014
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4K4D
| X-ray crystal structure of E. coli YbdB complexed with 2,4-dihydroxyphenacyl-CoA | Descriptor: | 2,4-dihydroxyphenacyl coenzyme A, ACETATE ION, MALONATE ION, ... | Authors: | Ru, W, Farelli, J.D, Dunaway-Mariano, D, Allen, K.N. | Deposit date: | 2013-04-12 | Release date: | 2014-07-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB. Biochemistry, 53, 2014
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2B0R
| Crystal Structure of Cyclase-Associated Protein from Cryptosporidium parvum | Descriptor: | UNKNOWN ATOM OR ION, possible adenyl cyclase-associated protein | Authors: | Tempel, W, Dong, A, Zhao, Y, Lew, J, Kozieradzki, I, Alam, Z, Melone, M, Wasney, G, Vedadi, M, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Hui, R, Bochkarev, A, Artz, J, Structural Genomics Consortium (SGC) | Deposit date: | 2005-09-14 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector J.Biol.Chem., 151, 2010
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