4XSD

Complex structure of thymidylate synthase from varicella zoster virus with a dUMP

Summary for 4XSD

Entry DOI	10.2210/pdb4xsd/pdb
Descriptor	Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (3 entities in total)
Functional Keywords	vzv, thymidylate synthase, herpesvirus, viral protein
Biological source	Varicella-zoster virus (strain Oka vaccine) (HHV-3)
Total number of polymer chains	4
Total formula weight	144308.12
Authors	Hew, K. (deposition date: 2015-01-22, release date: 2015-12-16, Last modification date: 2024-01-10)
Primary citation	Hew, K.,Dahlroth, S.L.,Veerappan, S.,Pan, L.X.,Cornvik, T.,Nordlund, P. Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10:e0143947-e0143947, 2015 Cited by PubMed: 26630264 DOI: 10.1371/journal.pone.0143947 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation