7P6N

ROCK2 IN COMPLEX WITH COMPOUND 12

Summary for 7P6N

Entry DOI	10.2210/pdb7p6n/pdb
Descriptor	Rho-associated protein kinase 2, ~{N}-[(1~{R})-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-yl-piperidine-1-carboxamide (2 entities in total)
Functional Keywords	rho-associated protein kinase 2, inhibitor complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	368322.76
Authors	Maillard, M.C. (deposition date: 2021-07-16, release date: 2022-07-27, Last modification date: 2023-08-09)
Primary citation	Ladduwahetty, T.,Lee, M.R.,Maillard, M.C.,Cachope, R.,Todd, D.,Barnes, M.,Beaumont, V.,Chauhan, A.,Gallati, C.,Haughan, A.F.,Kempf, G.,Luckhurst, C.A.,Matthews, K.,McAllister, G.,Mitchell, P.,Patel, H.,Rose, M.,Saville-Stones, E.,Steinbacher, S.,Stott, A.J.,Thatcher, E.,Tierney, J.,Urbonas, L.,Munoz-Sanjuan, I.,Dominguez, C. Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease. J.Med.Chem., 65:9819-9845, 2022 Cited by PubMed: 35816678 DOI: 10.1021/acs.jmedchem.2c00474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation