1YB3
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![BU of 1yb3 by Molmil](/molmil-images/mine/1yb3) | Conserved hypothetical protein Pfu-178653-001 from Pyrococcus furiosus | Descriptor: | UNKNOWN ATOM OR ION, hypothetical protein | Authors: | Habel, J, Zhou, W, Chang, J, Zhao, M, Xu, H, Chen, L, Lee, D, Nguyen, D, Chang, S.-H, Horanyi, P, Florence, Q, Tempel, W, Lin, D, Zhang, H, Praissman, J, Jenney Jr, F.E, Adams, M.W.W, Liu, Z.-J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2004-12-19 | Release date: | 2005-02-01 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Conserved hypothetical protein Pfu-178653-001 from Pyrococcus furiosus To be published
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1YBX
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![BU of 1ybx by Molmil](/molmil-images/mine/1ybx) | Conserved hypothetical protein Cth-383 from Clostridium thermocellum | Descriptor: | Conserved hypothetical protein, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Chang, J, Zhao, M, Habel, J, Kataeva, I, Xu, H, Chen, L, Lee, D, Nguyen, J, Chang, S.-H, Horanyi, P, Florence, Q, Zhou, W, Lin, D, Zhang, H, Ljundahl, L, Liu, Z.-J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2004-12-21 | Release date: | 2005-02-01 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Conserved hypothetical protein Cth-383 from Clostridium thermocellum To be published
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4YOM
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![BU of 4yom by Molmil](/molmil-images/mine/4yom) | Structure of SAD kinase | Descriptor: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase BRSK2 | Authors: | Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W. | Deposit date: | 2015-03-12 | Release date: | 2015-12-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural insight into the mechanism of synergistic autoinhibition of SAD kinases Nat Commun, 6, 2015
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1YD7
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![BU of 1yd7 by Molmil](/molmil-images/mine/1yd7) | Conserved hypothetical protein Pfu-1647980-001 from Pyrococcus furiosus | Descriptor: | 2-keto acid:ferredoxin oxidoreductase subunit alpha, UNKNOWN ATOM OR ION | Authors: | Horanyi, P, Florence, Q, Zhou, W, Chang, J, Zhao, M, Habel, J, Xu, H, Chen, L, Lee, D, Nguyen, D, Chang, S.-H, Tempel, W, Lin, D, Zhang, H, Praissman, J, Jenney Jr, F.E, Adams, M.W.W, Liu, Z.-J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2004-12-23 | Release date: | 2005-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conserved hypothetical protein Pfu-1647980-001 from Pyrococcus furiosus To be published
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5XKH
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![BU of 5xkh by Molmil](/molmil-images/mine/5xkh) | Crystal structure of T2R-TTL-CF1 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(4-methoxy-3-oxidanyl-phenyl)-methyl-amino]chromen-2-one, CALCIUM ION, ... | Authors: | Wang, Y, Yang, J, Wang, T, Chen, L. | Deposit date: | 2017-05-07 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors To Be Published
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4YNZ
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![BU of 4ynz by Molmil](/molmil-images/mine/4ynz) | Structure of the N-terminal domain of SAD | Descriptor: | Serine/threonine-protein kinase BRSK2 | Authors: | Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W. | Deposit date: | 2015-03-11 | Release date: | 2015-12-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insight into the mechanism of synergistic autoinhibition of SAD kinases Nat Commun, 6, 2015
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4EAJ
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![BU of 4eaj by Molmil](/molmil-images/mine/4eaj) | Co-crystal of AMPK core with AMP soaked with ATP | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | Authors: | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | Deposit date: | 2012-03-22 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.609 Å) | Cite: | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
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5XI5
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![BU of 5xi5 by Molmil](/molmil-images/mine/5xi5) | Crystal structure of T2R-TTL-PO5 complex | Descriptor: | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Chu, Y, Wang, Y, Yang, J, Li, W. | Deposit date: | 2017-04-26 | Release date: | 2017-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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4EQ8
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![BU of 4eq8 by Molmil](/molmil-images/mine/4eq8) | Crystal structure of PA1844 from Pseudomonas aeruginosa PAO1 | Descriptor: | GLYCEROL, Putative uncharacterized protein | Authors: | Shang, G, Li, N, Zhang, J, Lu, D, Yu, Q, Zhao, Y, Liu, X, Xu, S, Gu, L. | Deposit date: | 2012-04-18 | Release date: | 2012-09-12 | Last modified: | 2013-07-24 | Method: | X-RAY DIFFRACTION (1.392 Å) | Cite: | Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function. Biochem.J., 448, 2012
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5Z4U
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![BU of 5z4u by Molmil](/molmil-images/mine/5z4u) | Crystal Structure of T2R-TTL complex with 7a3 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(4-ethoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole, CALCIUM ION, ... | Authors: | Lai, Q, Wang, Y, Yang, J, Yao, Y. | Deposit date: | 2018-01-14 | Release date: | 2019-01-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Crystal Structure of T2R-TTL complex with 7a3 To Be Published
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1Y81
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![BU of 1y81 by Molmil](/molmil-images/mine/1y81) | Conserved hypothetical protein Pfu-723267-001 from Pyrococcus furiosus | Descriptor: | COENZYME A, THIOCYANATE ION, UNKNOWN ATOM OR ION, ... | Authors: | Zhao, M, Chang, J, Habel, J, Xu, H, Chen, L, Lee, D, Nguyen, D, Chang, S.-H, Horanyi, P, Florence, Q, Tempel, W, Zhou, W, Lin, D, Zhang, H, Praissman, J, Jenney Jr, F.E, Adams, M.W.W, Liu, Z.-J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2004-12-10 | Release date: | 2005-01-25 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Conserved hypothetical protein Pfu-723267-001 from Pyrococcus furiosus To be published
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7LYI
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![BU of 7lyi by Molmil](/molmil-images/mine/7lyi) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-3 | Descriptor: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | Authors: | Sacco, M, Wang, J, Chen, Y. | Deposit date: | 2021-03-07 | Release date: | 2021-03-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir. Acs Pharmacol Transl Sci, 4, 2021
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7LYH
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![BU of 7lyh by Molmil](/molmil-images/mine/7lyh) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-1 | Descriptor: | 3C-like proteinase, GLYCEROL, benzyl (1S,3aR,6aS)-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate | Authors: | Sacco, M, Wang, J, Chen, Y. | Deposit date: | 2021-03-07 | Release date: | 2021-03-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir. Acs Pharmacol Transl Sci, 4, 2021
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7C72
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![BU of 7c72 by Molmil](/molmil-images/mine/7c72) | Structure of a mycobacterium tuberculosis puromycin-hydrolyzing peptidase | Descriptor: | D-MALATE, GLYCEROL, Prolyl oligopeptidase | Authors: | Ruiz-Carrillo, D, Zhao, Y.H, Feng, Q, Zhou, X, Zhang, Y, Jiang, J, Lukman, M. | Deposit date: | 2020-05-22 | Release date: | 2021-03-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.00004458 Å) | Cite: | Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity. Proteins, 89, 2021
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7WQL
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![BU of 7wql by Molmil](/molmil-images/mine/7wql) | Bovin Beta-lactoglobulin binding with zinc ions | Descriptor: | Beta-lactoglobulin, ZINC ION | Authors: | Li, T, Ma, J, Zang, J, Zhao, G, Zhang, T. | Deposit date: | 2022-01-25 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Zinc binding strength of proteins dominants zinc uptake in Caco-2 cells. Rsc Adv, 12, 2022
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7XF3
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![BU of 7xf3 by Molmil](/molmil-images/mine/7xf3) | The structure of HLA-B*1501/BM58-66AF9 | Descriptor: | 9-mer peptide from Matrix protein 1, Beta-2-microglobulin, MHC class I antigen | Authors: | Zhao, Y.Z, Xiao, W.L, Wu, Y.N, Fan, W.F, Yue, C, Zhang, Q.X, Zhang, D.N, Yuan, X.J, Yao, S.J, Liu, S, Li, M, Wang, P.Y, Zhang, H.J, Zhang, J, Zhao, M, Zheng, X.Q, Liu, W.J, Gao, G.F, Liu, W.L. | Deposit date: | 2022-03-31 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Parallel T Cell Immunogenic Regions in Influenza B and A Viruses with Distinct Nuclear Export Signal Functions: The Balance between Viral Life Cycle and Immune Escape. J Immunol., 210, 2023
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7DR8
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![BU of 7dr8 by Molmil](/molmil-images/mine/7dr8) | Crystal structure of MERS-CoV 3CL protease in spacegroup P212121 | Descriptor: | 3C-like proteinase | Authors: | Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J. | Deposit date: | 2020-12-26 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.338149 Å) | Cite: | Crystal structure of MERS-CoV 3CL protease in spacegroup P212121 To Be Published
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7E2M
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![BU of 7e2m by Molmil](/molmil-images/mine/7e2m) | Crystal structure of the RWD domain of human GCN2 - 2 | Descriptor: | eIF-2-alpha kinase GCN2 | Authors: | Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. | Deposit date: | 2021-02-05 | Release date: | 2021-03-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
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7E2K
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![BU of 7e2k by Molmil](/molmil-images/mine/7e2k) | Crystal structure of the RWD domain of human GCN2 - 1 | Descriptor: | eIF-2-alpha kinase GCN2 | Authors: | Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. | Deposit date: | 2021-02-05 | Release date: | 2021-03-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.041 Å) | Cite: | Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
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5XI7
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![BU of 5xi7 by Molmil](/molmil-images/mine/5xi7) | Crystal structure of T2R-TTL bound with PO-7 | Descriptor: | (6Z)-3-[[2,5-bis(fluoranyl)phenyl]methylidene]-6-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Chu, Y, Wang, Y, Yang, J, Li, W. | Deposit date: | 2017-04-26 | Release date: | 2017-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents To Be Published
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7F6W
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![BU of 7f6w by Molmil](/molmil-images/mine/7f6w) | Crystal structure of Saccharomyces cerevisiae lysyl-tRNA Synthetase | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine--tRNA ligase | Authors: | Wu, S, Li, P, Hei, Z, Zheng, L, Wang, J, Fang, P. | Deposit date: | 2021-06-26 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.607 Å) | Cite: | Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex. Cell.Mol.Life Sci., 79, 2022
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3TYH
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![BU of 3tyh by Molmil](/molmil-images/mine/3tyh) | Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae | Descriptor: | COPPER (II) ION, FbpA protein | Authors: | Chen, W.J, Wang, H.F, Zhou, C.J, Ye, D.R, Huang, J, Tan, X.S, Zhong, W.Q. | Deposit date: | 2011-09-26 | Release date: | 2012-09-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae To be Published
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4EAG
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![BU of 4eag by Molmil](/molmil-images/mine/4eag) | Co-crystal structure of an chimeric AMPK core with ATP | Descriptor: | 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | Deposit date: | 2012-03-22 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
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4EAL
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![BU of 4eal by Molmil](/molmil-images/mine/4eal) | Co-crystal of AMPK core with ATP soaked with AMP | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | Authors: | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | Deposit date: | 2012-03-22 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.506 Å) | Cite: | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
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1YBY
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![BU of 1yby by Molmil](/molmil-images/mine/1yby) | Conserved hypothetical protein Cth-95 from Clostridium thermocellum | Descriptor: | Translation elongation factor P, UNKNOWN ATOM OR ION | Authors: | Zhao, M, Zhou, W, Chang, J, Habel, J, Kataeva, I, Xu, H, Chen, L, Lee, D, Nguyen, J, Chang, S.-H, Horanyi, P, Florence, Q, Tempel, W, Lin, D, Zhang, H, Ljundahl, L, Liu, Z.-J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2004-12-21 | Release date: | 2005-02-01 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Conserved hypothetical protein Cth-95 from Clostridium thermocellum To be published
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