7C7E
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![BU of 7c7e by Molmil](/molmil-images/mine/7c7e) | Crystal structure of C terminal domain of Escherichia coli DgoR | Descriptor: | Putative DNA-binding transcriptional regulator, SULFATE ION, TRIETHYLENE GLYCOL, ... | Authors: | Lin, W. | Deposit date: | 2020-05-25 | Release date: | 2021-01-20 | Method: | X-RAY DIFFRACTION (2.047 Å) | Cite: | Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket. Front Microbiol, 11, 2020
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3P57
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![BU of 3p57 by Molmil](/molmil-images/mine/3p57) | Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA | Descriptor: | DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), Histone acetyltransferase p300, ... | Authors: | He, J, Ye, J, Riquelme, C, Liu, J.O. | Deposit date: | 2010-10-08 | Release date: | 2011-08-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1921 Å) | Cite: | Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic Acids Res., 39, 2011
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8COO
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![BU of 8coo by Molmil](/molmil-images/mine/8coo) | Solution structure of Zipcode binding protein 1 (ZBP1) KH3(DD)KH4 domains in complex with N6-Methyladenosine containing RNA | Descriptor: | Insulin-like growth factor 2 mRNA-binding protein 1, RNA_(5'-R(*(UP*CP*GP*GP*(6MZ)P*CP*U)-3') | Authors: | Nicastro, G, Abis, G, Taylor, I.A, Ramos, A. | Deposit date: | 2023-02-28 | Release date: | 2024-02-07 | Method: | SOLUTION NMR | Cite: | Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers. Nucleic Acids Res., 51, 2023
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8D7M
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![BU of 8d7m by Molmil](/molmil-images/mine/8d7m) | Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide | Descriptor: | Casein kinase I isoform delta, Period circadian protein homolog 2 peptide | Authors: | Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. | Deposit date: | 2022-06-07 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
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8D7O
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![BU of 8d7o by Molmil](/molmil-images/mine/8d7o) | Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide | Descriptor: | Casein kinase I isoform delta, Period circadian protein homolog 2 peptide | Authors: | Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. | Deposit date: | 2022-06-07 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
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8D7P
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![BU of 8d7p by Molmil](/molmil-images/mine/8d7p) | Human Casein kinase 1 delta in complex with phosphorylated Drosophila PERIOD peptide | Descriptor: | Casein kinase I isoform delta, Period circadian protein peptide | Authors: | Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. | Deposit date: | 2022-06-07 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
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8D7N
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![BU of 8d7n by Molmil](/molmil-images/mine/8d7n) | Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide | Descriptor: | Casein kinase I isoform delta, Period circadian protein homolog 2 peptide | Authors: | Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. | Deposit date: | 2022-06-07 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
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5SZF
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![BU of 5szf by Molmil](/molmil-images/mine/5szf) | 2A10 FAB fragment 2.54 Angstoms | Descriptor: | 2A10 antibody FAB fragment heavy chain, 2A10 antibody FAB fragment light chain, SULFATE ION | Authors: | Jackson, C.J, Fisher, C. | Deposit date: | 2016-08-13 | Release date: | 2017-07-26 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein. PLoS Pathog., 13, 2017
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7BPB
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![BU of 7bpb by Molmil](/molmil-images/mine/7bpb) | Human AAA+ ATPase VCP mutant - T76E, AMP-PNP bound form, Conformation I | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Yang, C, Zhang, H. | Deposit date: | 2020-03-22 | Release date: | 2021-03-31 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. Cell Death Differ., 2022
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7BP9
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![BU of 7bp9 by Molmil](/molmil-images/mine/7bp9) | Human AAA+ ATPase VCP mutant - T76E, ADP-bound form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Yang, C, Zhang, H. | Deposit date: | 2020-03-21 | Release date: | 2021-03-31 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. Cell Death Differ., 2022
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7BP8
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![BU of 7bp8 by Molmil](/molmil-images/mine/7bp8) | Human AAA+ ATPase VCP mutant - T76A, ADP-bound form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Yang, C, Zhang, H. | Deposit date: | 2020-03-21 | Release date: | 2021-03-31 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. Cell Death Differ., 2022
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7BPA
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![BU of 7bpa by Molmil](/molmil-images/mine/7bpa) | Human AAA+ ATPase VCP mutant - T76A, AMP-PNP-bound form, Conformation I | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Yang, C, Zhang, H. | Deposit date: | 2020-03-21 | Release date: | 2021-03-31 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. Cell Death Differ., 2022
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3TW8
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![BU of 3tw8 by Molmil](/molmil-images/mine/3tw8) | GEF domain of DENND 1B in complex with Rab GTPase Rab35 | Descriptor: | DENN domain-containing protein 1B, Ras-related protein Rab-35 | Authors: | Wu, X.D, Kummel, D, Reinisch, K.M. | Deposit date: | 2011-09-21 | Release date: | 2011-11-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. Proc.Natl.Acad.Sci.USA, 108, 2011
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4DQE
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![BU of 4dqe by Molmil](/molmil-images/mine/4dqe) | Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, Aspartyl protease | Authors: | Schiffer, C.A, Mittal, S. | Deposit date: | 2012-02-15 | Release date: | 2012-03-07 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134, 2012
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4DQC
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![BU of 4dqc by Molmil](/molmil-images/mine/4dqc) | Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Aspartyl protease, GLYCEROL, ... | Authors: | Schiffer, C.A, Mittal, S. | Deposit date: | 2012-02-15 | Release date: | 2012-03-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134, 2012
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7M4R
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![BU of 7m4r by Molmil](/molmil-images/mine/7m4r) | |
4DQF
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![BU of 4dqf by Molmil](/molmil-images/mine/4dqf) | Crystal Structure of (G16A/L38A) HIV-1 Protease in Complex with DRV | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, 1,2-ETHANEDIOL, Aspartyl protease, ... | Authors: | Schiffer, C.A, Mittal, S. | Deposit date: | 2012-02-15 | Release date: | 2012-03-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134, 2012
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4DQH
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![BU of 4dqh by Molmil](/molmil-images/mine/4dqh) | Crystal Structure of (R14C/E65C) HIV-1 Protease in complex with DRV | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, GLYCEROL, Wild-type HIV-1 protease dimer | Authors: | Schiffer, C.A, Mittal, S. | Deposit date: | 2012-02-15 | Release date: | 2012-03-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134, 2012
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4DQB
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![BU of 4dqb by Molmil](/molmil-images/mine/4dqb) | Crystal Structure of wild-type HIV-1 Protease in Complex with DRV | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, 1,2-ETHANEDIOL, Aspartyl protease, ... | Authors: | Schiffer, C.A, Mittal, S. | Deposit date: | 2012-02-15 | Release date: | 2012-03-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134, 2012
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4DQG
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![BU of 4dqg by Molmil](/molmil-images/mine/4dqg) | |
6B20
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![BU of 6b20 by Molmil](/molmil-images/mine/6b20) | Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator | Descriptor: | CHLORIDE ION, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... | Authors: | Gulati, S, Kiser, P.D, Palczewski, K. | Deposit date: | 2017-09-19 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun, 9, 2018
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7EW4
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![BU of 7ew4 by Molmil](/molmil-images/mine/7ew4) | Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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7EW2
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![BU of 7ew2 by Molmil](/molmil-images/mine/7ew2) | Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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7EW3
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![BU of 7ew3 by Molmil](/molmil-images/mine/7ew3) | Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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7F83
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![BU of 7f83 by Molmil](/molmil-images/mine/7f83) | Crystal Structure of a receptor in Complex with inverse agonist | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone, Growth hormone secretagogue receptor type 1,Soluble cytochrome b562 | Authors: | Xu, Z, Shao, Z. | Deposit date: | 2021-07-01 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun, 13, 2022
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