8D7M

Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide

Summary for 8D7M

• Entry DOI: 10.2210/pdb8d7m/pdb
• Descriptor: Casein kinase I isoform delta, Period circadian protein homolog 2 peptide (3 entities in total)
• Functional Keywords: transferase, circadian clock protein, kinase, complex, transferase-circadian clock protein complex, transferase/circadian clock protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 72154.73

Authors

Philpott, J.M.,Freeberg, A.M.,Tripathi, S.M.,Partch, C.L. (deposition date: 2022-06-07, release date: 2023-05-17, Last modification date: 2023-10-25)

• Primary citation: Philpott, J.M.,Freeberg, A.M.,Park, J.,Lee, K.,Ricci, C.G.,Hunt, S.R.,Narasimamurthy, R.,Segal, D.H.,Robles, R.,Cai, Y.,Tripathi, S.,McCammon, J.A.,Virshup, D.M.,Chiu, J.C.,Lee, C.,Partch, C.L.; PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.; Mol.Cell, 83:1677-1692.e8, 2023; PubMed: 37207626; DOI: 10.1016/j.molcel.2023.04.019

Experimental method

X-RAY DIFFRACTION (2.25 Å)